A gland transplant that could end a lifetime of calcium shots?
NCT ID NCT05114980
First seen Aug 21, 2026 · Last updated Aug 21, 2026
Summary
This trial tests whether transplanting parathyroid glands from a donor can help people with severe hypoparathyroidism—a condition where the body can't regulate calcium, often after neck surgery. Participants are adults aged 18-80 who have had the condition for at least a year and still need IV calcium despite medical treatment. The study will see if the transplanted glands produce parathyroid hormone and reduce the need for calcium supplements, while also monitoring for side effects from immunosuppression.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Parathyroid allotransplantation (transplant of donor parathyroid glands)
- What this could lead to
- If successful, this could offer a lasting treatment—or even a cure—for people with severe hypoparathyroidism who don't respond to standard therapy.
- What could go wrong
- This is an early, experimental procedure performed at only a few centers worldwide. Risks include transplant rejection, complications from immunosuppression, and the possibility that the transplanted glands may not function long-term.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HYPOPARATHYROIDISM are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could a daily shot free teens from calcium pills?
- Weekly shot could free hypoparathyroidism patients from daily pills
- New daily shot could ease rare hormone disorder
- Glowing goggles could prevent calcium crash after thyroid surgery
- MRNA therapy offers hope for rare hormone disorder
- MRNA therapy takes on rare hormone disorder