Can antibody infusions shield CLL patients from deadly infections?

NCT ID NCT04502030

Completed Disease control Sponsor: Octapharma Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether regular infusions of Panzyga (a concentrated antibody solution from donated blood) could prevent serious infections in people with chronic lymphocytic leukemia (CLL) who also have low antibody levels. The trial included 247 adults with CLL who were receiving cancer treatment. Half got Panzyga, half got a placebo. The goal was to see if Panzyga reduced the number of major infections requiring hospitalization or leading to death.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Panzyga (a human antibody solution given intravenously)

What this could lead to

If it works, this could give CLL patients a way to prevent serious infections while on cancer treatment.

What could go wrong

This is a completed Phase 3 trial, but results are not yet published. The benefit may be modest, and IVIG infusions can cause side effects like headache, fever, or allergic reactions.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

agammaglobulinemia B-cell chronic lymphocytic leukemia syndromic agammaglobulinemia infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC LYMPHOCYTIC LEUKEMIA HYPOGAMMAGLOBULINEMIA

Contacts and locations

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Locations

Octapharma Research Site

St. Petersburg, Florida, 33709, United States
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Columbus, Georgia, 31904, United States
Octapharma Research Site

Macon, Georgia, 31201, United States
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New Orleans, Louisiana, 70112, United States
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Baltimore, Maryland, 21201, United States
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Baltimore, Maryland, 21205, United States
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Detroit, Michigan, 48093, United States
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Rochester, Minnesota, 55902, United States
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Buffalo, New York, 14260, United States
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New York, New York, 10032, United States
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New York, New York, 10065, United States
Octapharma Research Site

Shirley, New York, 11967, United States
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Durham, North Carolina, 27710, United States
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Charleston, South Carolina, 29414, United States
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Houston, Texas, 77090, United States
Octapharma Research Site

Brno, 625 00, Czechia
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Hradec Králové, 500 05, Czechia
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Ostrava, 70852, Czechia
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Aalborg, 9000, Denmark
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Herning, 7400, Denmark
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Roskilde, 4000, Denmark
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Dortmund, 44263, Germany
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Frankfurt, 15236, Germany
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Kiel, 24105, Germany
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Marburg, 35037, Germany
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Athens, 10676, Greece
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Athens, 11526, Greece
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Athens, 12462, Greece
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Ioannina, 45500, Greece
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Pátrai, 26500, Greece
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Thessaloniki, 57010, Greece
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Budapest, 1088, Hungary
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Debrecen, 4032, Hungary
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Győr, 9023, Hungary
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Kaposvár, 7400, Hungary
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Nyíregyháza, 4400, Hungary
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Haifa, 3109601, Israel
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Haifa, 34362, Israel
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Petah Tikva, 49100, Israel
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Castelfranco Veneto, 31033, Italy
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Milan, 20132, Italy
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Milan, 20162, Italy
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Modena, 41124, Italy
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Orbassano, 10043, Italy
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Padova, 35129, Italy
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Pescara, 65124, Italy
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Reggio Calabria, 89133, Italy
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Rome, 00161, Italy
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Torino, 10126, Italy
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Bialystok, 15-732, Poland
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Bydgoszcz, 85-065, Poland
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Gdansk, 80-214, Poland
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Gdansk, 80-219, Poland
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Gdynia, 81-519, Poland
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Katowice, 40-519, Poland
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Legnica, 59-220, Poland
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Lodz, 93-513, Poland
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Torun, 87-100, Poland
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Warsaw, 02-776, Poland
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Wroclaw, 50-367, Poland
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Barnaul, 656024, Russia
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Kemerovo, 650066, Russia
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Moscow, 115478, Russia
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Moscow, 125284, Russia
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Nizhny Novgorod, 603126, Russia
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Novosibirsk, 630051, Russia
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Petrozavodsk, 185019, Russia
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Rostov-on-Don, 344037, Russia
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Saint Petersburg, 191024, Russia
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Samara, 443079, Russia
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Tomsk, 634063, Russia
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Tula, 300053, Russia
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Ufa, 450008, Russia
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Yekaterinburg, 620102, Russia
Octapharma Research Site

Madrid, 28034, Spain
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Madrid, 28040, Spain
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Madrid, 28046, Spain
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Oviedo, 33011, Spain
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Santander, 39008, Spain
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Ankara, 65900, Turkey (Türkiye)
Octapharma Research Site

Antalya, 7050, Turkey (Türkiye)
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Istanbul, 34093, Turkey (Türkiye)
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Izmir, 35100, Turkey (Türkiye)
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Kayseri, 38039, Turkey (Türkiye)