New hope for stage IV breast cancer: adding surgery or radiation to targeted therapy

NCT ID NCT03870919

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether adding surgery or radiation to a standard drug combination (palbociclib plus letrozole) can help people with newly diagnosed stage IV ER+/HER2- breast cancer live longer. About 200 women with cancer that has spread beyond the breast will receive the drug combo, and some will also get local treatment on their breast tumor. The goal is to see if this combined approach improves overall survival compared to drugs alone.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm hormone receptor-positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • CH Cholet

    Cholet, 49300, France

  • CH René Dubos

    Pontoise, 95000, France

  • Centre Eugène Marquis

    Rennes, 35042, France

  • Centre François Baclesse

    Caen, France

  • Centre George François Leclerc

    Dijon, 21000, France

  • Centre Hospitalier de Pau

    Pau, 64000, France

  • Centre Jean Perrin

    Clermont-Ferrand, 63000, France

  • Centre Léon Bérard

    Lyon, 69008, France

  • GCS RISSA - Institut de cancérologie Paris Nord

    Sarcelles, 95200, France

  • Gustave Roussy

    Villejuif, 94800, France

  • Hôpital Privé à Saint Grégoire

    Saint-Grégoire, 35760, France

  • Hôpital Saint Louis APHP

    Paris, 75010, France

  • Hôpital St Joseph

    Marseille, 13008, France

  • Hôpital St Joseph

    Paris, 75014, France

  • Hôpital Tenon

    Paris, 75020, France

  • Hôpital privé sainte Marie

    Chalon-sur-Saône, 71100, France

  • Hôpital saint Eloi CHU Montpellier

    Montpellier, 34090, France

  • ICM Val d'Aurelle

    Montpellier, 34298, France

  • Institut Claudius Regaud

    Toulouse, 31059, France

  • Institut Curie Hôpital René Huguenin

    Saint-Cloud, 92210, France

  • Institut Curie Site Paris

    Paris, 75005, France

  • Institut Jean Godinot

    Reims, 51726, France

  • Institut Paoli Calmettes

    Marseille, 13009, France

  • Institut Sainte Catherine

    Avignon, 84818, France

  • Institut de Cancérologie de Lorraine

    Vandœuvre-lès-Nancy, 54519, France

  • Institut de Cancérologie de l'Ouest-Site Paul Papin

    Angers, 49005, France