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Liver drug trial for kids with biliary atresia ends early

NCT ID NCT06121375

Terminated Disease control Sponsor: Intercept Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 08, 2026 · Updated 3 times

Summary

This study tested the drug obeticholic acid in children with biliary atresia who had already undergone Kasai surgery. The goal was to see if the drug could improve outcomes like avoiding liver transplant or death. The trial was terminated early and enrolled only 28 participants, so results are limited.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
obeticholic acid
What this could lead to
If it had worked, this could have pointed toward a new treatment to delay or prevent liver transplant in children with biliary atresia.
What could go wrong
The trial was terminated early, so we don't have clear results. It was also a small study, and the drug may not have shown enough benefit or may have caused side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

biliary atresia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BILIARY ATRESIA

Contacts and locations

Locations

  • Akdeniz Üniversitesi Tıp Fakültesi Hastanesi Pediatrik Gastroenteroloji

    Konyaalti, Antalya, 07050, Turkey (Türkiye)

  • Alberta Childrens Hospital

    Calgary, Alberta, T3B 6A8, Canada

  • Children's Hospital of Fudan University

    Shanghai, China

  • Children's Hospital of Shanxi

    Taiyuan, China

  • Children's Hospital, Zhejiang University School of Medicine

    Hangzhou, Zhejiang, 310006, China

  • Childrens Hospital of Shanghai

    Shanghai, China

  • Ege Üniversitesi Hastanesi Pediatrik Gastroenteroloji Bölümü

    Bornova, İzmir, 35100, Turkey (Türkiye)

  • Guangzhou Women And Childrens Medical Center

    Guangzhou, China

  • Hacettepe Universitesi ihsan Dogramaci Cocuk Hastansesi

    Ankara, 06230, Turkey (Türkiye)

  • Hadassah Medical Center

    Jerusalem, Israel

  • Hospital Raja Perempuan Azinab II

    Kota Bharu, Kelantan, 15586, Malaysia

  • KK Women's and Children's Hospital

    Singapore, Singapore

  • Linkou Chang Gung Memorial Hospital

    Taoyuan, Taiwan

  • National Chen Kung University Hospital

    Tainan, Taiwan

  • National Taiwan University Hospital

    Taipei, Taiwan

  • Queen Mary Hospital

    Hong Kong, Hong Kong

  • Queensland Childrens Hospital

    South Brisbane, Queensland, 4101, Australia

  • Royal Childrens Hospital

    Parkville, Victoria, 3104, Australia

  • Shaare-Zedek Medical Center

    Jerusalem, Israel

  • Starship Child Health

    Auckland, 1142, New Zealand

  • Stollery Children's Hospital

    Edmonton, Alberta, Canada

  • Taichung Veterans General Hospital

    Taichung, Taiwan

  • University Malaya Medical Center

    Kuala Lumpur, 59100, Malaysia

  • Women's and Children's Hospital

    North Adelaide, South Australia, 5006, Australia

More trials for these conditions

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