Can a common Anti-Inflammatory replace opioids after ACL surgery?
NCT ID NCT06973785
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two pain medicines after ACL knee surgery: ketorolac (a non-steroidal anti-inflammatory) and oxycodone (a narcotic). Thirty patients will be randomly assigned to one of the two drugs and tracked for how many narcotic pills they need. The goal is to see if ketorolac can effectively control pain while reducing or eliminating the need for opioids.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ketorolac (Toradol)
What this could lead to
If it works, this could offer a non-narcotic pain control option after ACL surgery, reducing reliance on opioids.
What could go wrong
This is a small, early-phase trial with only 30 participants, so results may not apply broadly. Ketorolac may not control pain as well as narcotics for some patients.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cleveland Clinic
Strongsville, Ohio, 44136, United States
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Cleveland Clinic Coral Springs
Coral Springs, Florida, 33067, United States
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Cleveland clinic sports medicine
Garfield, Ohio, 44125, United States