New pill could cool menopause hot flashes without hormones

NCT ID NCT06385795

Completed Symptom relief Sponsor: Noema Pharma AG Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested an experimental drug called NOE-115 in 40 women aged 45 to 60 who have moderate to severe hot flashes due to menopause. The goal was to see if the drug is safe and can reduce symptoms. Participants took the drug for 4 weeks, and researchers tracked side effects and how well it worked.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: NOE-115
What this could lead to: If successful, this could point toward a new non-hormonal treatment option for hot flashes during menopause.
What could go wrong: This is a small, early-phase trial with only 40 women and no placebo group, so results may not be conclusive or apply to everyone. Side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Hot Flashes

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HOT FLASHES MENOPAUSE MENOPAUSE SYNDROME

Contacts and locations

Locations

Noema PMM-201 Site #101

Atlanta, Georgia, 30030, United States
Noema PMM-201 Site #102

Jacksonville, Florida, 32256, United States
Noema PMM-201 Site #103

Seattle, Washington, 98105, United States
Noema PMM-201 Site #104

San Diego, California, 92111, United States
Noema PMM-201 Site #106

Las Vegas, Nevada, 89106, United States

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