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Vitamin B3 supplement tested for better sleep and sharper minds

NCT ID NCT05500170

Symptom relief Sponsor: State University of New York at Buffalo Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 24, 2026 · Last updated Sep 25, 2026 · Updated 1 time

Summary

Researchers are testing whether a dietary supplement called nicotinamide riboside (NR), a form of vitamin B3, can improve sleep quality and cognitive function in older veterans who report poor sleep. NR is converted by the body into NAD+, a molecule linked to brain health, and low NAD+ levels have been associated with Alzheimer's disease and sleep problems. The study will give some participants NR and others a placebo pill, then measure sleep quality and thinking skills over time. The goal is to see whether boosting NAD+ through NR supplementation affects sleep and cognition, and whether it changes levels of a brain protein called BDNF.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nicotinamide riboside, a form of vitamin B3 sold as a dietary supplement
What this could lead to
If it works, this could point toward a low-cost supplement that helps older adults sleep better and think more clearly. It could also support further research into how NAD+ levels affect brain health.
What could go wrong
This is a small, early-stage study of 50 people, so any benefits seen may not hold up in larger trials. Supplements like NR are not proven to improve cognition or sleep, and the placebo-controlled design means some participants will not receive the active supplement.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2023

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 to 85 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Sleep Quality. Pittsburgh Sleep Quality Index (PSQI) global score \>5 Exclusion Criteria: * Dementia. Veteran Affairs - St. Louis University Mental Status questionnaire (VA-SLUMS) score \<20

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction insomnia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognitive impairment Sleep quality

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Buffalo Veteran Affairs Medical Center

    RECRUITING

    Buffalo, New York, 14215, United States

  • State University of New York at Buffalo

    NOT_YET_RECRUITING

    Buffalo, New York, 14203, United States

  • University at Buffalo State University of New York

    NOT_YET_RECRUITING

    Buffalo, New York, 14203, United States

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