New combo tackles meth cravings on demand

NCT ID NCT04791969

Completed Disease control Sponsor: Glenn-Milo Santos Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether taking naltrexone pills only when needed, combined with a smartphone app that offers real-time support, can help men who have sex with men reduce methamphetamine use. Sixty participants were randomly assigned to receive either the drug or a placebo, plus the app, for 12 weeks. The goal was to see if the approach could lower meth-positive urine tests and improve HIV prevention behaviors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: naltrexone (a drug that blocks opioid receptors, used here to reduce meth cravings)
What this could lead to: If it works, this could offer a practical, on-demand treatment to help men who have sex with men cut down meth use and lower their risk of HIV.
What could go wrong: This is a small, early-phase trial with only 60 participants, so results may not apply to everyone. The drug is taken only as needed, which may not work for all users.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

methamphetamine dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METHAMPHETAMINE USE DISORDER

Contacts and locations

Locations

San Francisco Department of Public Health

San Francisco, California, 94102, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.