MRI-Guided radiation: a sharper weapon against prostate cancer?

NCT ID NCT00913939

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tests a new way to deliver high-dose radiation to prostate tumors using real-time MRI guidance. It includes two groups: men whose prostate cancer has returned after prior radiation, and men with advanced cancer receiving standard external beam radiation plus this boost. The goal is to see if MRI guidance improves accuracy and tumor targeting in up to 500 patients.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
MRI-guided HDR brachytherapy
What this could lead to
If successful, this approach could make prostate cancer treatment more precise, potentially reducing side effects and improving outcomes for patients with recurrent or advanced disease.
What could go wrong
This is a pilot study focused on technical performance, not yet proven to improve survival. The procedure is complex and may carry risks like bleeding, infection, or urinary problems.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University Health Network, Princess Margaret Hospital

    RECRUITING

    Toronto, Ontario, M5G 2M9, Canada

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