Can a malaria drug help beat tough skin cancer?

NCT ID NCT04527549

Terminated Disease control Sponsor: ECOG-ACRIN Cancer Research Group Source: ClinicalTrials.gov ↗

Summary

This study tested whether adding the drug hydroxychloroquine to a standard two-drug treatment (dabrafenib and trametinib) could better control advanced melanoma that has a specific BRAF gene mutation. It aimed to see if the three-drug combo could delay cancer growth longer than the standard two-drug treatment alone. The trial was for patients whose cancer had progressed despite prior immunotherapy and who had a high blood marker (LDH).

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Alaska Breast Care and Surgery LLC

Anchorage, Alaska, 99508, United States
Alaska Oncology and Hematology LLC

Anchorage, Alaska, 99508, United States
Alaska Women's Cancer Care

Anchorage, Alaska, 99508, United States
Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, 68124, United States
Alegent Health Immanuel Medical Center

Omaha, Nebraska, 68122, United States
Alegent Health Lakeside Hospital

Omaha, Nebraska, 68130, United States
Alegent Health Mercy Hospital

Council Bluffs, Iowa, 51503, United States
Anchorage Associates in Radiation Medicine

Anchorage, Alaska, 98508, United States
Anchorage Oncology Centre

Anchorage, Alaska, 99508, United States
Anchorage Radiation Therapy Center

Anchorage, Alaska, 99504, United States
Armes Family Cancer Center

Findlay, Ohio, 45840, United States
Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, 45005-1066, United States
Bay Area Hospital

Coos Bay, Oregon, 97420, United States
Beebe Health Campus

Rehoboth Beach, Delaware, 19971, United States
Beebe Medical Center

Lewes, Delaware, 19958, United States
Beebe South Coastal Health Campus

Frankford, Delaware, 19945, United States
Bethesda North Hospital

Cincinnati, Ohio, 45242, United States
Blanchard Valley Hospital

Findlay, Ohio, 45840, United States
Broadlawns Medical Center

Des Moines, Iowa, 50314, United States
CHI Health Good Samaritan

Kearney, Nebraska, 68847, United States
CHI Health Saint Francis

Grand Island, Nebraska, 68803, United States
CHI Saint Vincent Cancer Center Hot Springs

Hot Springs, Arkansas, 71913, United States
Cancer Center at Saint Joseph's

Phoenix, Arizona, 85004, United States
Carle Cancer Center

Urbana, Illinois, 61801, United States
Carle Physician Group-Effingham

Effingham, Illinois, 62401, United States
Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938, United States
Carle on Vermilion

Danville, Illinois, 61832, United States
Cedars Sinai Medical Center

Los Angeles, California, 90048, United States
Central Care Cancer Center - Bolivar

Bolivar, Missouri, 65613, United States
Central Care Cancer Center - Garden City

Garden City, Kansas, 67846, United States
Central Care Cancer Center - Great Bend

Great Bend, Kansas, 67530, United States
Christiana Care Health System-Christiana Hospital

Newark, Delaware, 19718, United States
Christiana Care Health System-Concord Health Center

Chadds Ford, Pennsylvania, 19317, United States
Christiana Care Health System-Wilmington Hospital

Wilmington, Delaware, 19801, United States
Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015, United States
Commonwealth Cancer Center-Corbin

Corbin, Kentucky, 40701, United States
Cox Cancer Center Branson

Branson, Missouri, 65616, United States
CoxHealth South Hospital

Springfield, Missouri, 65807, United States
Creighton University Medical Center

Omaha, Nebraska, 68131, United States
Dayton Physician LLC-Miami Valley Hospital North

Dayton, Ohio, 45415, United States
Dayton Physicians LLC-Atrium

Franklin, Ohio, 45005, United States
Dayton Physicians LLC-Miami Valley South

Centerville, Ohio, 45459, United States
Dayton Physicians LLC-Upper Valley

Troy, Ohio, 45373, United States
Dayton Physicians LLC-Wayne

Greenville, Ohio, 45331, United States
Delaware Clinical and Laboratory Physicians PA

Newark, Delaware, 19713, United States
Delbert Day Cancer Institute at PCRMC

Rolla, Missouri, 65401, United States
Flaget Memorial Hospital

Bardstown, Kentucky, 40004, United States
Franciscan Research Center-Northwest Medical Plaza

Tacoma, Washington, 98405, United States
Freeman Health System

Joplin, Missouri, 64804, United States
Good Samaritan Hospital - Cincinnati

Cincinnati, Ohio, 45220, United States
Good Samaritan Regional Health Center

Mount Vernon, Illinois, 62864, United States
Greater Dayton Cancer Center

Kettering, Ohio, 45409, United States
Greater Regional Medical Center

Creston, Iowa, 50801, United States
Harrison HealthPartners Hematology and Oncology-Bremerton

Bremerton, Washington, 98310, United States
Harrison HealthPartners Hematology and Oncology-Poulsbo

Poulsbo, Washington, 98370, United States
Harrison Medical Center

Bremerton, Washington, 98310, United States
Heartland Regional Medical Center

Saint Joseph, Missouri, 64506, United States
Helen F Graham Cancer Center

Newark, Delaware, 19713, United States
Highline Medical Center-Main Campus

Burien, Washington, 98166, United States
Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States
Indu and Raj Soin Medical Center

Beavercreek, Ohio, 45431, United States
Iowa Lutheran Hospital

Des Moines, Iowa, 50316, United States
Iowa Methodist Medical Center

Des Moines, Iowa, 50309, United States
Jewish Hospital

Louisville, Kentucky, 40202, United States
Jewish Hospital Medical Center South

Shepherdsville, Kentucky, 40165, United States
Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336, United States
Katmai Oncology Group

Anchorage, Alaska, 99508, United States
Kettering Medical Center

Kettering, Ohio, 45429, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016, United States
Littleton Adventist Hospital

Littleton, Colorado, 80122, United States
Longmont United Hospital

Longmont, Colorado, 80501, United States
Loyola Center for Health at Burr Ridge

Burr Ridge, Illinois, 60527, United States
Loyola Medicine Homer Glen

Homer Glen, Illinois, 60491, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
Marjorie Weinberg Cancer Center at Loyola-Gottlieb

Melrose Park, Illinois, 60160, United States
Marshfield Clinic - Ladysmith Center

Ladysmith, Wisconsin, 54848, United States
Marshfield Clinic - Wisconsin Rapids Center

Wisconsin Rapids, Wisconsin, 54494, United States
Marshfield Clinic-Chippewa Center

Chippewa Falls, Wisconsin, 54729, United States
Marshfield Clinic-Minocqua Center

Minocqua, Wisconsin, 54548, United States
Marshfield Clinic-Wausau Center

Wausau, Wisconsin, 54401, United States
Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States
Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701, United States
Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States
Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States
Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482, United States
Mary Greeley Medical Center

Ames, Iowa, 50010, United States
Mayo Clinic Hospital in Arizona

Phoenix, Arizona, 85054, United States
Mayo Clinic in Arizona

Scottsdale, Arizona, 85259, United States
Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States
McFarland Clinic PC - Ames

Ames, Iowa, 50010, United States
McFarland Clinic PC-Boone

Boone, Iowa, 50036, United States
McFarland Clinic PC-Jefferson

Jefferson, Iowa, 50129, United States
McFarland Clinic PC-Marshalltown

Marshalltown, Iowa, 50158, United States
McFarland Clinic PC-Trinity Cancer Center

Fort Dodge, Iowa, 50501, United States
MedStar Franklin Square Medical Center/Weinberg Cancer Institute

Baltimore, Maryland, 21237, United States
MedStar Georgetown University Hospital

Washington D.C., District of Columbia, 20007, United States
Medical Oncology Hematology Consultants PA

Newark, Delaware, 19713, United States
Medical Oncology and Hematology Associates-Des Moines

Des Moines, Iowa, 50309, United States
Medical Oncology and Hematology Associates-West Des Moines

Clive, Iowa, 50325, United States
Mercy Cancer Center-West Lakes

Clive, Iowa, 50325, United States
Mercy Clinic-Rolla-Cancer and Hematology

Rolla, Missouri, 65401, United States
Mercy Hospital Fort Smith

Fort Smith, Arkansas, 72903, United States
Mercy Hospital Joplin

Joplin, Missouri, 64804, United States
Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, 73120, United States
Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States
Mercy Hospital South

St Louis, Missouri, 63128, United States
Mercy Hospital Springfield

Springfield, Missouri, 65804, United States
Mercy Hospital Washington

Washington, Missouri, 63090, United States
Mercy Medical Center

Durango, Colorado, 81301, United States
Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States
Mercy Medical Center-West Lakes

West Des Moines, Iowa, 50266, United States
Methodist West Hospital

West Des Moines, Iowa, 50266-7700, United States
Miami Valley Hospital

Dayton, Ohio, 45409, United States
Miami Valley Hospital North

Dayton, Ohio, 45415, United States
Miami Valley Hospital South

Centerville, Ohio, 45459, United States
Midlands Community Hospital

Papillion, Nebraska, 68046, United States
Mission Cancer and Blood - Laurel

Des Moines, Iowa, 50314, United States
Mission Hope Medical Oncology - Arroyo Grande

Arroyo Grande, California, 93420, United States
Mission Hope Medical Oncology - Santa Maria

Santa Maria, California, 93444, United States
Oncology Hematology Care Inc-Kenwood

Cincinnati, Ohio, 45236, United States
Orion Cancer Care

Findlay, Ohio, 45840, United States
Pacific Central Coast Health Center-San Luis Obispo

San Luis Obispo, California, 93401, United States
Pacific Gynecology Specialists

Seattle, Washington, 98104, United States
Parker Adventist Hospital

Parker, Colorado, 80138, United States
PeaceHealth Saint John Medical Center

Longview, Washington, 98632, United States
PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, 98225, United States
PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664, United States
PeaceHealth United General Medical Center

Sedro-Woolley, Washington, 98284, United States
Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States
Porter Adventist Hospital

Denver, Colorado, 80210, United States
Providence Alaska Medical Center

Anchorage, Alaska, 99508, United States
Providence Cancer Institute Clackamas Clinic

Clackamas, Oregon, 97015, United States
Providence Newberg Medical Center

Newberg, Oregon, 97132, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Providence Regional Cancer Partnership

Everett, Washington, 98201, United States
Providence Regional Cancer System-Aberdeen

Aberdeen, Washington, 98520, United States
Providence Regional Cancer System-Centralia

Centralia, Washington, 98531, United States
Providence Regional Cancer System-Lacey

Lacey, Washington, 98503, United States
Providence Regional Cancer System-Shelton

Shelton, Washington, 98584, United States
Providence Regional Cancer System-Yelm

Yelm, Washington, 98597, United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, 91505, United States
Providence Saint Mary Regional Cancer Center

Walla Walla, Washington, 99362, United States
Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States
Reid Health

Richmond, Indiana, 47374, United States
Rocky Mountain Cancer Centers-Longmont

Longmont, Colorado, 80501, United States
Rocky Mountain Cancer Centers-Penrose

Colorado Springs, Colorado, 80907, United States
Rush - Copley Medical Center

Aurora, Illinois, 60504, United States
Rush-Copley Healthcare Center

Yorkville, Illinois, 60560, United States
Saint Anthony Hospital

Lakewood, Colorado, 80228, United States
Saint Anthony Regional Hospital

Carroll, Iowa, 51401, United States
Saint Anthony's Health

Alton, Illinois, 62002, United States
Saint Charles Health System

Bend, Oregon, 97701, United States
Saint Charles Health System-Redmond

Redmond, Oregon, 97756, United States
Saint Clare Hospital

Lakewood, Washington, 98499, United States
Saint Elizabeth Boardman Hospital

Boardman, Ohio, 44512, United States
Saint Elizabeth Hospital

Enumclaw, Washington, 98022, United States
Saint Elizabeth Regional Medical Center

Lincoln, Nebraska, 68510, United States
Saint Elizabeth Youngstown Hospital

Youngstown, Ohio, 44501, United States
Saint Francis Cancer Center

Colorado Springs, Colorado, 80923, United States
Saint Francis Hospital

Federal Way, Washington, 98003, United States
Saint Joseph Hospital East

Lexington, Kentucky, 40509, United States
Saint Joseph London

London, Kentucky, 40741, United States
Saint Joseph Radiation Oncology Resource Center

Lexington, Kentucky, 40504, United States
Saint Joseph Regional Cancer Center

Bryan, Texas, 77802, United States
Saint Joseph Warren Hospital

Warren, Ohio, 44484, United States
Saint Louis Cancer and Breast Institute-Ballwin

Ballwin, Missouri, 63011, United States
Saint Louis Cancer and Breast Institute-South City

St Louis, Missouri, 63109, United States
Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83686, United States
Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301, United States
Saint Mary Corwin Medical Center

Pueblo, Colorado, 81004, United States
Saint Patrick Hospital - Community Hospital

Missoula, Montana, 59802, United States
Saints Mary and Elizabeth Hospital

Louisville, Kentucky, 40215, United States
Southwest Oncology PC

Durango, Colorado, 81301, United States
Springfield Regional Cancer Center

Springfield, Ohio, 45504, United States
Springfield Regional Medical Center

Springfield, Ohio, 45505, United States
Swedish Cancer Institute-Edmonds

Edmonds, Washington, 98026, United States
Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029, United States
Swedish Medical Center-Ballard Campus

Seattle, Washington, 98107, United States
Swedish Medical Center-Cherry Hill

Seattle, Washington, 98122-5711, United States
Swedish Medical Center-First Hill

Seattle, Washington, 98122, United States
The Carle Foundation Hospital

Urbana, Illinois, 61801, United States
TidalHealth Nanticoke / Allen Cancer Center

Seaford, Delaware, 19973, United States
TriHealth Cancer Institute-Anderson

Cincinnati, Ohio, 45255, United States
TriHealth Cancer Institute-Westside

Cincinnati, Ohio, 45247, United States
Trinity Regional Medical Center

Fort Dodge, Iowa, 50501, United States
UM Sylvester Comprehensive Cancer Center at Aventura

Aventura, Florida, 33180, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, 33146, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, 33442, United States
UM Sylvester Comprehensive Cancer Center at Kendall

Miami, Florida, 33176, United States
UM Sylvester Comprehensive Cancer Center at Plantation

Plantation, Florida, 33324, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States
University of Pennsylvania/Abramson Cancer Center

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232, United States
UofL Health Medical Center Northeast

Louisville, Kentucky, 40245, United States
Upper Valley Medical Center

Troy, Ohio, 45373, United States
Wayne Hospital

Greenville, Ohio, 45331, United States

Conditions

Explore the condition pages connected to this study.

CLINICAL STAGE IV CUTANEOUS MELANOMA AJCC V8 LOCALLY ADVANCED MELANOMA PATHOLOGIC STAGE IIIC CUTANEOUS MELANOMA AJCC V8 PATHOLOGIC STAGE IV CUTANEOUS MELANOMA AJCC V8 UNRESECTABLE MELANOMA