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Spesolimab shows promise for Long-Term control of painful hand and foot pustules

NCT ID NCT04493424

Terminated Disease control Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at the long-term safety of spesolimab for people with palmoplantar pustulosis, a chronic skin condition causing painful pustules on hands and feet. Participants who benefited from spesolimab in earlier trials can continue treatment for up to 5 years, with monthly injections and regular check-ups. The goal is to see if the drug remains safe and helps control symptoms over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
spesolimab
What this could lead to
If successful, this could show that spesolimab is safe and effective for long-term control of palmoplantar pustulosis, offering a treatment option for this chronic skin condition.
What could go wrong
This is a small, early-phase extension study that was terminated early, so results may be limited. Long-term safety and effectiveness are not yet proven, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

palmoplantar pustulosis psoriasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PALMOPLANTAR PUSTULOSIS

Contacts and locations

Locations

  • Asahikawa Medical University Hospital

    Hokkaido, Asahikawa, 078-8510, Japan

  • Barbara Rewerska Diamond Clinic, Krakow

    Krakow, 31-559, Poland

  • Brussels - UNIV Saint-Luc

    Brussels, 1200, Belgium

  • CCBR Czech a.s.

    Pardubice, 530 02, Czechia

  • Charité - Universitätsmedizin Berlin

    Berlin, 10117, Germany

  • Dermatovenereological Dispensary #10, St. Petersburg

    Saint Petersburg, 194021, Russia

  • Dermmedica Sp. z o.o., Wroclaw

    Wroclaw, 51-318, Poland

  • Dermoklinika medical center, Lodz

    Lodz, 90-436, Poland

  • Dr. Irina Turchin PC Inc.

    Fredericton, New Brunswick, E3B 1G9, Canada

  • Fujita Health University Hospital

    Aichi, Toyoake, 470-1192, Japan

  • Fukuoka University Hospital

    Fukuoka, Fukuoka, 814-0180, Japan

  • Gachon University Gil Medical Center

    Incheon, 21565, South Korea

  • Gifu University Hospital

    Gifu, Gifu, 501-1194, Japan

  • Guy's Hospital

    London, SE1 9RT, United Kingdom

  • HOP Larrey

    Toulouse, 31059, France

  • HOP Saint-Louis

    Paris, 75010, France

  • HOP l'Archet

    Nice, 06200, France

  • Independent Public Clin.Hosp.no1 Lublin

    Lublin, 20-081, Poland

  • Innovaderm Research Inc.

    Montreal, Quebec, H2X 2V1, Canada

  • Jichi Medical University Hospital

    Tochigi, Shimotsuke, 329-0498, Japan

  • Kumamoto University Hospital

    Kumamoto, Kumamoto, 860-8556, Japan

  • LLC "Medical Center Azbuka Zdorovia"

    Kazan', 420111, Russia

  • Markusovszky University Teaching Hospital

    Szombathely, 9700, Hungary

  • Menter Dermatology Research Institute

    Dallas, Texas, 75246, United States

  • Municipal Hospital Complex in Olsztyn

    Olsztyn, 10-229, Poland

  • Nakatsu Dermatology Clinic

    Osaka, Osaka, 531-0071, Japan

  • National Taiwan University Hospital

    Taipei, 10002, Taiwan

  • Nihon University Itabashi Hospital

    Tokyo, Itabashi-ku, 173-8610, Japan

  • Okayama University Hospital

    Okayama, Okayama, 700-8558, Japan

  • Osaka Metropolitan University Hospital

    Osaka, Osaka, 545-8586, Japan

  • Osaka University Hospital

    Osaka, Suita, 565-0871, Japan

  • Paratus Clinical Research Woden

    Phillip, Australian Capital Territory, 2606, Australia

  • Royal Devon and Exeter Hospital

    Exeter, EX2 5DW, United Kingdom

  • Royal Melbourne Hospital

    Parkville, Victoria, 3050, Australia

  • SBHI Chelyabinsk Reg.Clin.Derma.Dispen.

    Chelyabinsk, 454048, Russia

  • Sagamihara National Hospital

    Kanagawa, Sagamihara, 252-0392, Japan

  • Sanatorium Prof. Arenebergera

    Prague, 11000, Czechia

  • Seoul National University Bundang Hospital

    Seongnam, 13620, South Korea

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Shiga University of Medical Science Hospital

    Shiga, Otsu, 520-2192, Japan

  • Shinshu University Hospital

    Nagano, Matsumoto, 390-8621, Japan

  • SimcoDerm Medical and Surgical Dermatology Centre

    Barrie, Ontario, L4M 7G1, Canada

  • Skin Health Institute Inc

    Carlton, Victoria, 3053, Australia

  • Takagi Dermatological Clinic

    Hokkaido, Obihiro, 080-0013, Japan

  • Takamatsu Red Cross Hospital

    Kagawa, Takamatsu, 760-0017, Japan

  • Teikyo University Hospital

    Tokyo, Itabashi-ku, 173-8606, Japan

  • The Guenther Dermatology Research Centre

    London, Ontario, N6A 3H7, Canada

  • The Psoriasis Treatment Center of Central New Jersey

    East Windsor, New Jersey, 08520, United States

  • Tohoku University Hospital

    Miyagi, Sendai, 980-8574, Japan

  • Tokyo Dental College Ichikawa General Hospital

    Chiba, Ichikawa, 272-8513, Japan

  • Tokyo Medical University Hospital

    Tokyo, Shinjuku-ku, 160-0023, Japan

  • Total Skin and Beauty Dermatology Center, PC

    Birmingham, Alabama, 35205, United States

  • UZ Leuven

    Leuven, 3000, Belgium

  • Univ. Hospital Kralovske Vinohrady

    Prague, 100 34, Czechia

  • University Hospital Kyoto Prefectural University of Medicine

    Kyoto, Kyoto, 602-8566, Japan

  • University of Missouri Health System

    Columbia, Missouri, 65212, United States

  • University of Pecs

    Pécs, 7632, Hungary

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15213, United States

  • University of Utah Health

    Murray, Utah, 84107, United States

  • University of the Ryukyus Hospital

    Okinawa, Nakagami-gun, 903-0215, Japan

  • Universitätsklinikum Erlangen

    Erlangen, 91054, Germany

  • Universitätsklinikum Frankfurt

    Frankfurt am Main, 60596, Germany

  • Universitätsklinikum Heidelberg

    Heidelberg, 69120, Germany

  • Universitätsklinikum Schleswig-Holstein, Campus Kiel

    Kiel, 24105, Germany

  • Wakayama Medical University Hospital

    Wakayama, Wakayama, 641-8509, Japan

  • Westmead Hospital

    Westmead, New South Wales, 2145, Australia

More trials for these conditions

Other studies related to the condition(s) this trial covers.