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Knee surgery Face-Off: does more trauma mean more inflammation?

NCT ID NCT05735847

Knowledge-focused Sponsor: Hvidovre University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 22, 2026 · Last updated Sep 23, 2026 · Updated 1 time

Summary

Researchers are studying whether total knee replacement causes a larger inflammatory response than partial knee replacement. The study enrolls adults with knee osteoarthritis who are candidates for either procedure. Participants give blood samples after surgery to measure markers of inflammation, and researchers track their recovery for two years to see if inflammation levels relate to how well patients do.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If the study shows that total knee replacement triggers more inflammation than partial knee replacement, doctors could use that information to better match patients to the right procedure and improve recovery.
What could go wrong
This is a small observational study of 29 people, so it cannot prove cause and effect. Inflammation markers in blood may not fully explain differences in pain or function after surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

29 people

The number who actually took part.

Started

Feb 2023

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Study participants will be adults (i.e. at least 18 years old) who have diagnosis of KOA with an indication for primary KA (medial unicondylar or total arthroplasty).

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 or more * A clinical and radiological diagnosis of knee OA * Candidate for spinal anaesthesia * signed informed consent Exclusion Criteria: * Planned surgery within the observation period other than KA * Any contraindications to the use of torniquet during surgery * Any contraindication to the administration of pre-operative dexamethasone * KA indication due to sequelae of e.g. fracture(s) * Previous infection of the target knee joint * Injection of medication or substances in the target knee within 3 months prior to participation * Immuno-inflammatory arthritis as cause of knee OA * Known autoimmune and/or inflammatory disease e.g. colitis ulcerosa * Active cancer diagnosis with ongoing treatment * Current systemic treatment with glucocorticoids equivalent to \> 7.5 mg prednisolone/day * Surgery requiring spinal/general anaesthesia within the last 3 months prior to inclusion * Infection requiring medical/surgical treatment within the last 4 weeks prior to surgery for KA * Neurological dysfunction compromising mobility * Inability to understand or read Danish incl. instructions and questionnaires * Any other condition or impairment that, in the opinion of the investigator (or his/her delegate), makes a potential participant unsuitable for participation or which obstruct participation.

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Conditions

The condition(s) this trial relates to.

arthritic joint disease osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Arthritis Knee osteoarthritis Surgery Total knee arthroplasty Unicompartmental knee arthroplasty

Contacts and locations

Locations

  • Department of Orthopaedic Surgery, Amager Hvidovre Hospital

    Hvidovre, 2650, Denmark

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