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Joint fluid analysis may unlock personalized knee osteoarthritis care

NCT ID NCT05416255

Knowledge-focused Sponsor: Dharma Bioscience Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 28, 2026 · Last updated Aug 28, 2026

Summary

This study tests whether measuring components in knee joint fluid can reveal how different treatments affect osteoarthritis. Researchers will collect fluid from 80 people with severe knee osteoarthritis, then give them either a dextrose injection, a stem cell injection, a platelet-rich plasma injection, or no injection. They will measure changes in fluid components from day 0 to day 7 or 14, and also track pain and function scores. The goal is to understand the biological changes behind these treatments, not to prove a cure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Measuring synovial fluid components, with optional injections of dextrose, hematopoietic stem cells, or platelet-rich plasma
What this could lead to
If it works, this could point toward a way to predict which knee osteoarthritis treatments work best for each person.
What could go wrong
This is an early, small study focused on measuring changes in joint fluid, not on proving a treatment works. The results may not apply to everyone with knee osteoarthritis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

80 people

The number who actually took part.

Started

Apr 2022

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria:≥ 6 months of knee pain with walking * ≥ 6/10 on a 0-10 point numerical rating scale * High grade medial compartment cartilage loss ( Kellgren-Lawrence grade 3 or 4) on plain weight bearing X-ray * Exposed subchondral bone at 110 degrees of flexion by ultrasound examination * Easily visible suprapatellar pouch with quads conttraction. Exclusion Criteria * Current intake of NSAIDs or steroids * Current anticoagulation therapy * Inflammatory or post-infectious knee arthritis * Systemic inflammatory conditions * Knee flexion less than 100 degrees * Knee extension less than 165 degrees * Valgus or varus more than 15 degrees * Any knee injection in the precedign 3 months * BMI more than 50 kg/ meter squared * Gross synovial folds on ultrasound.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis

Contacts and locations

Locations

  • Dharma Centro de Medicina Regenerativa

    Rosario, Santa Fe Province, 2000, Argentina

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