Cure My Disease

Don't miss your cure!

 Log in / Sign up

Can a nerve procedure outlast another for stubborn knee pain?

NCT ID NCT07805161

Symptom relief Sponsor: Saglik Bilimleri Universitesi Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 04, 2026 · Last updated Sep 04, 2026

Summary

This study compares two ultrasound-guided procedures that target nerves around the knee to relieve chronic osteoarthritis pain that has not improved with standard care. One procedure uses heat from radiofrequency to disable the nerves, while the other uses a chemical called phenol. Researchers will measure pain levels and knee function before treatment and at 4, 12, and 24 weeks after, to see which approach offers better and safer relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Two procedures: ultrasound-guided bipolar radiofrequency ablation and ultrasound-guided phenol chemical neurolysis of the genicular nerves
What this could lead to
If one procedure proves more effective, it could offer a longer-lasting, non-surgical option for people with knee osteoarthritis pain that has not responded to other treatments.
What could go wrong
This is an observational study, not a randomized trial, so results may be influenced by patient differences. Pain relief may be temporary, and procedures carry risks like infection, bleeding, or nerve damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

69 people

The number who actually took part.

Started

Aug 2024

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 to 75 years * Unilateral moderate-to-severe knee pain due to gonarthrosis * Numeric Rating Scale (NRS) score ≥6 * Knee pain lasting longer than 6 months * Radiological diagnosis of knee osteoarthritis, Kellgren-Lawrence grade 2-4 * Failure of conservative treatments, including analgesic medications, physical therapy, or intra-articular injections * At least 50% pain relief after diagnostic genicular nerve block * Ability to provide written informed consent Exclusion Criteria: * Knee pain due to causes other than osteoarthritis, such as fracture, trauma, spinal disorder, or inflammatory arthritis * Previous knee surgery * Knee joint effusion detected on physical examination or ultrasound * Cognitive impairment * Hepatic or renal failure * Severe psychiatric disorder * Local or systemic infection * Coagulopathy * Current use of antiplatelet or anticoagulant therapy * Presence of a pacemaker * Intra-articular injection or interventional knee procedure within the previous 6 months

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Gonarthrosis are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gonarthrosis

Contacts and locations

Locations

  • University Of Health Sciences, Gulhane School Of Medicine, Department Of Algology

    Ankara, Etlik, 06010, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.