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Blood enzymes eyed as possible window into knee arthritis

NCT ID NCT07875296

Knowledge-focused Sponsor: Afyonkarahisar Health Sciences University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Oct 15, 2026 · Last updated Oct 16, 2026 · Updated 1 time

Summary

Researchers at Afyonkarahisar Health Sciences University are studying whether blood levels of certain enzymes differ between women with knee osteoarthritis and healthy women. The enzymes, lysyl oxidase and lysyl hydroxylase, help build and cross-link collagen, the main structural protein in cartilage. The study enrolls 200 women aged 40 to 70, some with knee osteoarthritis at various stages and some without, and compares their enzyme levels alongside ultrasound measurements of knee cartilage thickness.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If enzyme levels track with osteoarthritis severity, doctors might one day use a simple blood test to gauge joint damage or spot the disease earlier.
What could go wrong
This is an observational study, so it cannot prove that these enzymes cause osteoarthritis or that changing them helps. A single blood measurement also captures only one moment in a long, slowly changing disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of female volunteers aged 40-70 years who are either diagnosed with knee osteoarthritis or are healthy controls without clinical or radiographic evidence of osteoarthritis. Participants will be recruited from the outpatient clinic of the Department of Physical Medicine and Rehabilitation, Afyonkarahisar Health Sciences University (AFSU). All participants will meet the inclusion criteria and provide written informed consent prior to enrollment. Individuals with metabolic diseases, inflammatory arthritis, or significant comorbidities will be excluded.

Ages

40 to 70 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female participants aged between 40 and 70 years. * Diagnosed with knee osteoarthritis according to clinical and radiographic criteria, and presenting to the Department of Physical Medicine and Rehabilitation, Afyonkarahisar Health Sciences University (AFSU). * Body Mass Index (BMI) between 18.5 and 40 kg/m². Exclusion Criteria: * Presence of metabolic diseases or severe comorbidities, including uncontrolled diabetes mellitus, chronic kidney disease (GFR \< 60 mL/min/1.73 m²), liver failure, malignancy, severe cardiovascular disease, chronic respiratory disorders, or chronic intestinal diseases. * Any inflammatory arthritis or other rheumatologic disease with related signs or symptoms. * History of knee trauma involving cruciate ligaments or menisci within the past 3 months. * Secondary osteoarthritis due to other joint disorders such as septic arthritis, avascular necrosis, or Paget's disease. * History of previous knee surgery. * Recent intra-articular injection to the knee joint within the last 3 months.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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  3. A doctor treating you

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Contacts and locations

Locations

  • Afyonkarahisar Health Sciences University, Department of Physical Medicine and Rehabilitation

    RECRUITING

    Afyonkarahisar, 03030, Turkey (Türkiye)

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