Can a drug cocktail stop Post-Surgery brain fog in seniors?
NCT ID NCT07627906
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two drug combinations—ketofol (ketamine plus propofol) and ketodex (ketamine plus dexmedetomidine)—to see which better prevents postoperative delirium in patients 60 and older undergoing open cancer surgery in the pelvis or abdomen. Delirium is a common, serious complication that can lead to longer hospital stays and worse outcomes. The trial will enroll 180 people and measure confusion two hours after surgery using a standard test.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Ketofol (ketamine and propofol mixture) and Ketodex (ketamine and dexmedetomidine mixture)
What this could lead to
If one of these drug combos works better, it could give doctors a simple way to prevent serious confusion after major cancer surgery in older patients.
What could go wrong
This is a single-center trial with 180 people, so results may not apply to everyone. Both combos have side effects like low blood pressure or slow heart rate, and it's unclear if either will truly prevent delirium.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Kasr Alainy Faculty of Medicine- Cairo University
RECRUITINGCairo, Cairo Governorate, 11728, Egypt
Contact Phone: •••-•••-•••• Email: •••••@•••••