Nasal spray may curb Post-Surgery confusion in seniors

NCT ID NCT07579806

Not yet recruiting Symptom relief Sponsor: Sichuan Provincial People's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a nasal spray containing dexmedetomidine can reduce the chance of postoperative delirium (sudden confusion) in people 65 and older after lung surgery. About 264 participants will be randomly assigned to get either the drug or a placebo spray before surgery. Researchers will track confusion, pain, sleep quality, and side effects for three days after the operation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dexmedetomidine hydrochloride nasal spray
What this could lead to: If it works, this could offer a simple, non-invasive way to lower the risk of confusion after lung surgery in older adults.
What could go wrong: This is a single, mid-sized trial. The effect may be small or not better than placebo, and side effects like low blood pressure or slow heart rate are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Emergence Delirium

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTOPERATIVE DELIRIUM (POD)

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Other studies related to the condition(s) this trial covers.