Cancer drug ixazomib tested as potential MS treatment
NCT ID NCT03783416
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 2 times
Summary
This phase 1b trial is testing whether ixazomib, a drug already used for multiple myeloma, is safe for people with multiple sclerosis. The study will enroll 72 adults with relapsing-remitting or progressive MS. Participants will receive either ixazomib or a placebo for up to 24 months, and researchers will monitor side effects and look for changes in immune markers in the spinal fluid.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ixazomib (NINLARO)
- What this could lead to
- If it works, this could point toward a new way to control multiple sclerosis by targeting the immune cells that drive the disease.
- What could go wrong
- This is a very early phase 1b trial with only 72 people, so it is primarily checking safety. It may not show clear benefit, and ixazomib has known side effects from its use in cancer.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Royal London Hospital, Barts Health NHS Foundation Trust
RECRUITINGLondon, Greater London, E1 1BB, United Kingdom
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