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Can tailored ventilation keep lungs safer during surgery?

NCT ID NCT07775573

Knowledge-focused Sponsor: Fatih Sultan Mehmet Training and Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time

Summary

This study looks at whether adjusting the ventilator's positive end-expiratory pressure (PEEP) to each patient individually can improve oxygen levels during laparoscopic inguinal hernia surgery, compared to using a standard fixed setting. Oxygenation is monitored continuously with a non-invasive sensor, and lung aeration is checked with ultrasound before and after surgery. The trial involves 60 adults aged 18-75 scheduled for elective hernia repair, aiming to see if a personalized approach helps keep the lungs open and working well during anesthesia.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Individualized positive end-expiratory pressure (PEEP) ventilation
What this could lead to
If individualized PEEP improves oxygenation during surgery, it could lead to better lung protection and fewer breathing complications after laparoscopic procedures.
What could go wrong
This is a small observational study, so results may not apply to all patients. Individualized PEEP may not always be better than standard settings, and the approach adds complexity.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients scheduled for elective laparoscopic unilateral inguinal hernia repair under general anesthesia at Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 18-75 years * ASA physical status I-III * Scheduled for elective laparoscopic unilateral inguinal hernia repair under general anesthesia * Body mass index (BMI) \< 35 kg/m² * Written informed consent obtained Exclusion Criteria: * Age below 18 or above 75 years * ASA physical status IV-V * Emergency surgical procedure * Severe chronic or restrictive pulmonary disease * Pulmonary hypertension * Obstructive sleep apnea syndrome * Preoperative peripheral oxygen saturation \< 94% on room air * Respiratory tract infection within the last two weeks * Severe cardiac failure (NYHA III-IV) * Pregnancy * Communication difficulties preventing NRS assessment * Surgical complications during the procedure * Operation duration exceeding 3 hours * Refusal to provide informed consent

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Conditions

The condition(s) this trial relates to.

Pneumoperitoneum Pulmonary Atelectasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atelectasis Laparoscopic inguinal hernia repair Mechanical ventilation Perioperative oxygenation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Istanbul Provincial Health Directorate Fatih Sultan Mehmet Training and Research Hospital

    Istanbul, 34000, Turkey (Türkiye)

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