Immune cells engineered to hunt brain tumors enter first human test

NCT ID NCT04661384

First seen Feb 21, 2026 · Last updated May 19, 2026 · Updated 18 times

Summary

This early-phase trial tests whether specially engineered immune cells (IL13Rα2-CAR T cells) can safely target and destroy brain tumor cells that have spread to the lining of the brain and spinal cord. Ten adults with glioblastoma, ependymoma, or medulloblastoma will receive these cells. The main goals are to check for side effects and measure how long participants live.

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Contacts and locations

Locations

  • City of Hope Medical Center

    Duarte, California, 91010, United States

Conditions

Explore the condition pages connected to this study.