MRI maps Low-Oxygen tumor zones to sharpen radiation strike

NCT ID NCT07769918

NEW Not yet recruiting Disease control Sponsor: NYU Langone Health Source: ClinicalTrials.gov ↗

First seen Aug 18, 2026 · Last updated Aug 18, 2026

Summary

This trial explores whether a special MRI technique can pinpoint low-oxygen (hypoxic) areas within glioblastoma, a type of aggressive brain tumor. In the first phase, researchers will check if these MRI maps match real tissue samples. In the second phase, they will use the maps to guide a targeted radiation boost to those resistant regions in patients receiving standard radiotherapy. The goal is to see if this approach is safe and feasible, and whether it might improve outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Hypoxia-targeted radiotherapy boost guided by DSC-MRI
What this could lead to: If successful, this approach could make radiation therapy more precise for glioblastoma, potentially improving tumor control and survival.
What could go wrong: This is a small early-phase study, so results may not apply broadly. The technique may not reliably identify hypoxic regions, and the added radiation boost could increase side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

glioblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOBLASTOMA (GBM)

Contacts and locations

Locations

NYU Langone Health

New York, New York, 10016, United States

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Other studies related to the condition(s) this trial covers.