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Human sperm cryopreservation as an alternative to the decline of sperm quality with aging

NCT ID NCT07814235

NEW Sponsor: IVI Murcia Source: ClinicalTrials.gov ↗

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Recruiting now This study
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By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
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Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Not a trial. The treatment could once be requested outside a study, but no longer can.
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When the status isn't known

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First seen Sep 10, 2026 · Last updated Sep 10, 2026

Summary

This observational study will evaluate whether sperm cryopreservation can help preserve sperm quality and molecular characteristics that may be affected by increasing paternal age. Men aged 18 years and older will provide a semen sample and a blood sample for laboratory analysis. Each semen sample will be divided into fresh, slow-frozen, and vitrified aliquots. The study will compare sperm quality (as assessed by computer-assisted sperm analysis), DNA methylation profiles, DNA fragmentation, sperm telomere length before and after cryopreservation. The effects of age on these parameters will also be assessed. The impact of age on seminal plasma extracellular vesicle composition and blood cell telomere length will also be analysed. The goal is to determine whether sperm cryopreservation may represent a strategy for preserving sperm characteristics associated with younger paternal age.

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Study facts

What this study's own registry entry says, in plain language.

Participants

About 45 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult men aged 18-65 years attending IVI Murcia for semen analysis, fertility assessment, semen donation, or assisted reproduction treatment who meet the study eligibility criteria and provide informed consent. Participants will provide semen and blood samples for laboratory assessment of sperm quality and molecular characteristics before and after cryopreservation.

Ages

18 to 65 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male participants aged 18 to 65 years * Attending IVI Murcia for semen analysis and/or assisted reproduction treatment * Able and willing to provide written informed consent * Willing to provide a semen sample and a blood sample for research purposes Exclusion Criteria: * Previous diagnosis of azoospermia or severe oligozoospermia (sperm concentration \<1 million sperm/mL) * Known chromosomal abnormality (abnormal karyotype) * Known Y chromosome microdeletion * Febrile illness within the previous 3 months * Presence of varicocele * Current use of vitamin or antioxidant supplements intended to improve semen quality

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Conditions

The condition(s) this trial relates to.

infertility disorder male infertility

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Assisted reproduction technologies Epigenetic aging Infertility Male fertility

How to take part

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  1. The places running it

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  2. The official record

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  3. A doctor treating you

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Contacts and locations

Locations

  • IVI Murcia

    RECRUITING

    Murcia, Murcia, 30007, Spain

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