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Estrogen drop may hold clue to bladder leaks in women with spinal cord injury

NCT ID NCT06892080

Knowledge-focused Sponsor: Swiss Paraplegic Research, Nottwil Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time

Summary

Women with spinal cord injury often deal with urinary incontinence, but most research has focused on women after menopause. This pilot study asks whether the natural drop in estrogen after ovulation could make incontinence more frequent. Twenty-four women will track their menstrual cycles and incontinence episodes for three months using diaries and urine tests. The goal is to understand whether hormones play a role, which could help doctors tailor treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If researchers find a link between hormone shifts and incontinence, it could guide better timing of treatment for women with spinal cord injury.
What could go wrong
This is a small pilot study with 24 women, so it can only hint at patterns. It cannot prove cause and effect, and the findings may not apply to women with different types of spinal cord injury or those using hormonal contraception.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 24 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Nov 2029

An estimate. End dates often move.

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Female outpatients of the Swiss Paraplegic Centre.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * women * age ≥ 18 years * chronic neurogenic bladder dysfunction due to acquired spinal cord injury * regular menstrual cycle (26-30 days/cycle) * written consent given * UI group only: UI at least once per month Exclusion Criteria: * Detrusor overactivity in storage phase above 15cmH20 * Oligomenorrhea or amenorrhea (infrequent or absent menstrual periods) * Hormonal intake/contraception * Intake of androgens * Intake of drugs which interfere with female sex hormones significantly * Individuals who underwent sex reassignment surgery * Pregnant or breastfeeding women * Women who are trying to conceive * Gynaecological carcinoma * Endometriosis * Ovariectomy * Current pelvic floor physiotherapy * Reconstructive surgery of bladder * Local irritation of the bladder, such as bladder tumour, bladder stones, acute urinary tract infection at study start * Inability to follow study procedures (cognitive or language barriers)

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Conditions

The condition(s) this trial relates to.

spinal cord injury Urinary Incontinence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Menstrual cycle Spinal cord injury Urinary incontinence

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Swiss Paraplegic Center

    RECRUITING

    Nottwil, 6207, Switzerland

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