Heart check: do Nerve-Targeting drugs also shield the heart in rare amyloidosis?
NCT ID NCT05873868
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study follows 20 adults with hereditary transthyretin amyloidosis (ATTRv) who have both nerve and heart involvement. They are treated with patisiran or vutrisiran for two years. Researchers use MRI scans and questionnaires to see how the drugs affect heart structure and function.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
patisiran or vutrisiran
What this could lead to
If successful, this could clarify whether these drugs protect the heart in mixed-form ATTRv amyloidosis, guiding future treatment decisions.
What could go wrong
This is a small observational study (20 people) with no control group, so results may not prove cause and effect or apply broadly.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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APHP Henri Mondor
Créteil, France
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CHU Bordeaux Haut-Levêque
Bordeaux, France
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CHU Grenoble Alpes
Grenoble, France
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CHU Nancy Institut Louis Mathieu
Nancy, France
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CHU Rangueil Toulouse
Toulouse, France