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Migraines and tension headaches may be hidden companions to multiple sclerosis

NCT ID NCT07826221

Knowledge-focused Sponsor: Assiut University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time

Summary

Researchers at Assiut University Hospitals are studying how often adults with multiple sclerosis also get primary headaches such as migraine and tension-type headache. About 100 patients will complete a single visit that includes a neurological exam, headache history, disability scoring, MRI review, and questionnaires about thinking, anxiety, and depression. The study uses standard international criteria to classify headache types. No experimental drugs or procedures are involved.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If researchers find that primary headaches are common in people with multiple sclerosis, doctors may start asking about headache symptoms during routine MS visits and treating them alongside other MS care.
What could go wrong
This is a single-center observational study of 100 people in Egypt, so the results may not reflect MS patients elsewhere. It cannot prove that MS causes headaches, only whether the two appear together.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients aged 18 years and older diagnosed with multiple sclerosis (including relapsing-remitting, secondary progressive, and primary progressive phenotypes) who attend the Multiple Sclerosis Clinic or are admitted to the Department of Neurology and Psychiatry at Assiut University Hospitals during the one-year study period.

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients aged 18 years or older * Confirmed diagnosis of multiple sclerosis according to the McDonald diagnostic criteria * Any clinical multiple sclerosis phenotype, including Relapsing-Remitting MS (RRMS), Secondary Progressive MS (SPMS), or Primary Progressive MS (PPMS) * Patients attending the Multiple Sclerosis Clinic or admitted to the Department of Neurology and Psychiatry at Assiut University Hospitals during the study period * Ability to understand study procedures and provide written informed consent Exclusion Criteria: * Other inflammatory demyelinating disorders of the central nervous system (e.g., neuromyelitis optica spectrum disorder \[NMOSD\] or myelin oligodendrocyte glycoprotein antibody-associated disease \[MOGAD\]) * Secondary headache attributable to identifiable non-MS etiologies, including intracranial tumors, central nervous system infections, acute cerebrovascular disease, idiopathic intracranial hypertension, or cerebral venous sinus thrombosis * Severe cognitive impairment or active psychiatric disorder precluding reliable clinical history-taking or completion of the structured headache assessment * Incomplete clinical or radiological records

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Conditions

The condition(s) this trial relates to.

anxiety disorder Depression headache disorder hypnic headache migraine disorder multiple sclerosis Tension-Type Headache

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Migraine disorders Multiple sclerosis Primary headache disorders Tension-type headache

How to take part

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  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

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