Can exercise rebuild muscle and balance in MS?
NCT ID NCT06595394
First seen Sep 18, 2026 · Last updated Sep 18, 2026
Summary
Researchers are testing whether a combined exercise program can improve muscle thickness, balance, and fall risk in people with multiple sclerosis who also have sarcopenia, a condition involving loss of muscle mass and strength. Participants in the exercise group attend 60-minute sessions three times a week for eight weeks, doing aerobic, balance, and strengthening exercises. A comparison group follows a home physiotherapy program. The trial measures muscle thickness with ultrasound and uses questionnaires and balance tests before and after the eight weeks.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- a combined exercise training program of aerobic, balance, and strengthening exercises
- What this could lead to
- If it works, this could point toward a structured exercise plan that helps people with multiple sclerosis and muscle loss keep their strength, balance, and independence.
- What could go wrong
- This is a small study of 28 people over 8 weeks, so any changes may be modest and may not last or apply to everyone with MS. Exercise can also cause temporary soreness or fatigue, and some participants may not complete the program.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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28 people
The number who actually took part.
- Started
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Oct 2024
- Finished
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Aug 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 50 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * People diagnosed with MS by a neurologist * People with ambulation whose EDSS is 4.5 or below * People between the ages of 18-50 * People who do not exercise regularly and are not included in an exercise program Exclusion Criteria: * Having been diagnosed with sarcopenia before MS diagnosis * Having had an MS attack within the last 30 days * Having any musculoskeletal problems that may affect walking and balance * Having a diagnosed psychiatric disease that may affect cognitive status * Having a neurological disease other than MS
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Uskudar University
Istanbul, Turkey (Türkiye)
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