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Could gut bacteria predict lung trouble after surgery?

NCT ID NCT06513416

Knowledge-focused Sponsor: Peking Union Medical College Hospital Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
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First seen Sep 16, 2026 · Last updated Sep 17, 2026 · Updated 1 time

Summary

Researchers are studying whether the mix of bacteria in an older person's gut before major abdominal surgery relates to breathing problems afterward, such as low oxygen, collapsed lung, or pneumonia. The study follows 265 patients aged 65 and older who are scheduled for elective abdominal surgery lasting at least two hours under general anesthesia. Stool and blood samples are collected before surgery, and outcomes are tracked afterward. A closer genetic analysis compares patients who develop lung complications with those who do not.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If a link holds up, doctors could one day check a patient's gut bacteria before surgery and take steps to lower the risk of lung problems afterward.
What could go wrong
This is an observational study, so it can show a pattern but not prove that gut bacteria cause lung complications. Findings from one hospital group may not apply to other patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

265 people

The number who actually took part.

Started

May 2023

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Elderly patients over 65 years old who plan to undergo elective major abdominal surgery

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age: ≥ 65 years old; 2. Surgery: Major abdominal surgery (expected duration ≥ 2 hours); 3. Anesthesia methods: general anesthesia, tracheal intubation; 4. ASA classification: I-IV levels; 5. Postoperative Pulmonary Complications Risk Score (ARISCAT): Medium to High Risk 6. Patients or their families are able to understand the research protocol and are willing to participate in this study, providing written informed consent Exclusion Criteria: 1. Emergency surgery; 2. This is the second surgery within the past month; 3. Preoperative presence of pulmonary infection or other serious pulmonary complications 4. Patients who have used antibiotics, probiotics, and acid suppressants within one month before surgery

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gut microbiota Postoperative pulmonary complications

Contacts and locations

Locations

  • Department of Anesthesiology, Peking Union Medical College Hospital

    Beijing, Beijing Municipality, 100730, China

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