Can a menopause-mimicking drug fight fatty liver in endometriosis patients?

NCT ID NCT06523530

Ongoing Disease control Sponsor: Aristotle University Of Thessaloniki Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 2 times

Summary

This study tests whether goserelin acetate, a drug that temporarily stops menstruation (like a short-term menopause), can reduce liver fat in women with endometriosis who also have fatty liver disease. Researchers will measure liver fat and stiffness using ultrasound in 62 women over 6 months. The goal is to see if this approach can improve liver health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Goserelin acetate (Zoladex), a drug that temporarily stops menstruation
What this could lead to: If it works, this could point toward a new way to treat fatty liver disease in women with endometriosis by using a temporary menopause-like state.
What could go wrong: This is a small, early-phase trial with only 62 participants. The drug causes temporary menopause, which may have side effects like hot flashes and bone thinning, and the liver benefit is not yet proven.

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Conditions

The condition(s) this trial relates to.

cirrhosis of liver endometriosis fatty liver disease metabolic dysfunction-associated steatotic liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIOSIS METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE NONALCOHOLIC FATTY LIVER

Contacts and locations

Locations

1st Department of Obstetrics and Gynecology, School of Medicine, Aristotle University of Thessaloniki

Thessaloniki, 56403, Greece
424 General Military Hospital

Thessaloniki, Thessaloniki, 56429, Greece

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