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One operation for cataract and glaucoma? eye surgeons test a Two-in-One approach

NCT ID NCT07821827

Disease control Sponsor: Assiut University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 16, 2026 · Last updated Sep 17, 2026 · Updated 1 time

Summary

Researchers at Assiut University are studying whether combining cataract surgery with a procedure called goniotomy safely lowers eye pressure and reduces the need for glaucoma medications. The trial enrolls 70 adults with cataract plus either primary open-angle or primary angle-closure glaucoma. Everyone receives the same combined operation, and doctors track eye pressure, medication use, vision, and complications for at least six months. The goal is to compare how well the approach works in the two different types of glaucoma.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
combined cataract surgery (phacoemulsification) and goniotomy, a procedure that opens the eye's drainage angle
What this could lead to
If it works, this combined approach could offer a single operation that lowers eye pressure and cuts the number of daily glaucoma drops for people who have both cataract and glaucoma.
What could go wrong
The trial is small and does not compare the combined surgery against standard glaucoma operations, so any benefit may not hold up in larger studies. Goniotomy can cause bleeding in the eye, and some people may still need extra pressure-lowering treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 40 years and older (no upper limit). * Diagnosis of uncontrolled or progressive primary open-angle glaucoma (POAG) or primary angle-closure glaucoma (PACG). * Presence of visually significant cataract requiring phacoemulsification. * Willingness and ability to complete the postoperative follow-up schedule of at least 6 months. Exclusion Criteria: * Secondary glaucoma. * Prior incisional glaucoma surgery or selective laser trabeculoplasty (SLT) in the study eye. * Corneal opacity preventing adequate gonioscopic visualization of the angle. * Associated retinal disease or non-glaucomatous optic nerve disease. * Inability or unwillingness to adhere to the follow-up schedule.

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Conditions

The condition(s) this trial relates to.

angle-closure glaucoma cataract open-angle glaucoma primary angle-closure glaucoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cataract Primary angle-closure glaucoma Primary open-angle glaucoma

How to take part

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  1. The official record

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  2. A doctor treating you

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