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Freeze or burn? two nerve treatments go head to head for knee arthritis

NCT ID NCT07855367

Symptom relief Sponsor: National Cancer Institute, Egypt Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Oct 02, 2026 · Last updated Oct 02, 2026

Summary

Researchers compare two procedures that target the genicular nerves, which carry pain signals from the knee. One uses cold to freeze the nerves, the other uses heat from radiofrequency energy. The trial enrolls 30 adults aged 40 and older with painful knee osteoarthritis that has not improved with other treatment. Doctors guide both procedures with ultrasound and track pain scores and knee function over time to see which method eases pain more.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nerve treatments that freeze or heat the genicular nerves in the knee
What this could lead to
If one method works better, doctors could pick the more effective nerve treatment for people whose knee arthritis pain persists after standard care.
What could go wrong
The trial is small, with 30 people, and compares two procedures rather than testing a new drug. Nerve ablation can leave lasting numbness or make pain worse, and results in this group may not apply to everyone with knee arthritis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2026

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 40 years * Symptomatic knee osteoarthritis (OA) in bladder cancer patient \[based on American College of Radiology (ACR) criteria\] * Radiological OA (Kellgren-Lawrence grade III-IV) * Chronic knee pain ≥ 3-6 months * Numerical Rating Scale (NRS) ≥ 5 despite conservative treatment * Positive diagnostic genicular nerve block (\>50% pain relief). Exclusion Criteria: * Prior genicular nerve ablation * Coagulopathy * Local infection * Severe deformity * Neuropathic pain syndromes * Uncontrolled comorbidities

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bipolar radiofrequency ablation Cryoneurolysis Genicular nerves Knee osteoarthritis Pain relief Symptomatic

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Cairo University

    RECRUITING

    Cairo, 12613, Egypt

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