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Single antibiotic dose may prevent Post-Surgery infections as well as a 5-Day course

NCT ID NCT07355907

Prevention Sponsor: Tanta University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a single dose of the antibiotic fosfomycin trometamol could prevent infections after kidney stone surgery as effectively as a 5-day course of levofloxacin. 210 adults undergoing surgery were randomly assigned to one of the two treatments or a control group. The goal was to see which approach better reduced post-surgery infections and sepsis.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
fosfomycin trometamol and levofloxacin
What this could lead to
If successful, a single dose of fosfomycin could replace longer antibiotic courses to prevent infections after kidney stone surgery.
What could go wrong
This is a completed trial with 210 participants, so results are available but may not apply to all patients or settings. Antibiotic resistance or side effects remain possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

210 people

The number who actually took part.

Started

Jan 2023

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

15 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * adult patients with renal stones scheduled for PCNL Exclusion Criteria: * Unfit patients for surgery * patients with active UT * uncorrected coagulopathy * pregnancy * children

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Conditions

The condition(s) this trial relates to.

Infections infectious disease Kidney Calculi nephrolithiasis Sepsis infectious disease with sepsis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Calculi, renal Infectious complications PCNL

Contacts and locations

Locations

  • Faculty of medicine, Tanta University

    Tanta, 11511, Egypt

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