Can a targeted electric pulse treatment spare prostate cancer patients from radical surgery?

NCT ID NCT05513443

First seen Aug 07, 2026 ยท Last updated Aug 07, 2026

Summary

This trial tests whether a focal treatment called irreversible electroporation (IRE) can control localized prostate cancer as effectively as radical treatments, but with fewer side effects. IRE uses high-voltage electrical pulses to destroy tumor cells while sparing surrounding healthy tissue. The study includes men with MRI-visible, unifocal prostate cancer who are eligible for radical treatment. The main goals are to compare urinary continence and irritative urinary symptoms between the two approaches, with secondary focus on erectile function.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
Irreversible electroporation (IRE), a procedure using high-voltage electrical pulses to destroy tumor cells
What this could lead to
If successful, this could offer a less invasive treatment option for localized prostate cancer that controls the tumor while preserving urinary and sexual function.
What could go wrong
The trial is relatively small and early-stage, and IRE may not control the cancer as effectively as radical treatments. There are also risks of side effects from the procedure itself.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Karolinska Institutet

    Stockholm, Solna, 17177, Sweden

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