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Can tiny beads block pain signals from arthritic spine joints?

NCT ID NCT06965452

Disease control Sponsor: Northwell Health Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 01, 2026 · Last updated Sep 02, 2026 · Updated 1 time

Summary

This trial tests a procedure called trans-arterial embolization for people with chronic back pain caused by facet joint arthritis. Doctors inject tiny beads into the blood vessels feeding the painful joints to reduce blood flow and potentially ease pain. The study includes 40 adults aged 18 to 85 who have not improved with standard treatments like injections or nerve procedures. The main goal is to check whether the procedure is safe and feasible, with a secondary focus on pain relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Trans-arterial embolization using Embozene Microspheres, a procedure that injects tiny beads into blood vessels to reduce blood flow to the painful facet joints
What this could lead to
If it works, this could offer a new, minimally invasive option for people with chronic back pain from facet joint arthritis who have not found relief with other treatments.
What could go wrong
This is an early, small study focused on safety and feasibility, so the procedure may not prove effective or may carry risks like bleeding or damage to nearby tissues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-85 * Confirmed diagnosis of spinal facet arthropathy on MRI OR CT * Confirmed diagnosis of lumbosacral facetogenic pain based on diagnostic nerve blocks. * Failed medical management of pain. * Back pain persistent for at least 6 months * Pain worse than at least 6/10 on a visual analog pain scale * Failed at least one of either intra-articular injections of steroids/ anesthetics or neuro-ablative procedure. * Maximum of 2 spinal levels of facetogenic pain in the lumbar and sacral spine (i.e. L4-5 and L5-S1). * Modified Rankin Scale 0-2 Exclusion Criteria: * \- Pregnancy * History of prior spinal embolization at the target level. * History of surgery/ stenting of the aorta at the level of embolization. * Severe allergic reaction to iodinated contrast (i.e. anaphylaxis) * Creatinine \> 1.5 mg/dl and/or creatinine clearance \< 60 mL/min (except if patients is already on hemodialysis). * Modified Rankin Scale \>2 * Angiographic/ Procedural Exclusion Criterion: Vascular supply to the spinal cord from the vessels supplying the facet joints targeted for embolization.

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Conditions

The condition(s) this trial relates to.

Back Pain Low Back Pain osteoarthritis Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Facet joint arthropathy Osteoarthritis Pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • North Shore University Hospital

    RECRUITING

    Manhasset, New York, 11030, United States

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