Exercise and diabetes risk: does family history matter?
NCT ID NCT02745613
First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time
Summary
This study investigates whether having a family history of type 2 diabetes changes how much exercise improves insulin sensitivity and blood sugar control. Researchers will measure insulin sensitivity, long-term and post-meal blood sugar levels, and blood sugar variability in 50 sedentary or moderately active adults. Participants will follow an 8-week combined exercise program to see if family history, prediabetes status, or sex influence the benefits.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- 8-week combined exercise program
- What this could lead to
- If successful, this could help tailor exercise recommendations for people with a family history of type 2 diabetes to improve insulin sensitivity.
- What could go wrong
- This is a small, early-stage study (50 participants) that may not apply to everyone. Results depend on adherence to the exercise program and individual differences.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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50 people
The number who actually took part.
- Start date
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Apr 2016
- Finished
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May 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Sedentary/moderately active lifestyle * Less than 150 minutes/wk. of structured exercise * Physical activity level ≤ 1.4 Exclusion Criteria: * Evidence of significant cardiovascular disease * Screening blood pressure \>140/90 * Pregnancy or breastfeeding * Use of drugs affecting energy metabolism or body weight * Excess alcohol, drug abuse, and smoking * Eating disorder or eating attitudes interfering with study * Excessively or active individuals * Unwillingness to abide by randomization * Injury that prevents the performance of exercise
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Texas at El Paso
El Paso, Texas, 79968, United States
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