Estrogen cream may cut surgery complications in boys with birth defect
NCT ID NCT01370798
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested whether applying estrogen cream to the penis for two months before surgery reduces complications in boys with severe hypospadias, a birth defect where the urethra opening is not at the tip. 244 boys aged 9-36 months received either estrogen cream or a placebo cream daily before undergoing urethroplasty. The goal was to see if estrogen improves healing and lowers the risk of fistulas or wound breakdown after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
promestriene (estrogen) cream
What this could lead to
If it works, this could reduce the need for repeat surgeries in boys with severe hypospadias.
What could go wrong
This is a completed phase 3 trial, but results may not apply to all cases. Estrogen cream may cause local irritation or hormonal effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Hôpital Mère-Enfant
Nantes, 44093, France
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Hôpital NECKER
Paris, 75015, France
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Hôpital Robert Debré
Paris, 72015, France
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Service de Chirurgie Pédiatrique Uro-génitale, Hopital femme Mere Enfant
Bron, 69677, France