New study aims to find best pain block for gallbladder surgery

NCT ID NCT06900413

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study compares two types of nerve blocks—ESP and EXORA—for managing pain after laparoscopic gallbladder removal. Fifty-six adults having elective surgery will be randomly assigned to receive one of the blocks. The goal is to see which block provides better pain relief and reduces the need for additional painkillers in the first 24 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nerve block (local anesthetic injection)
What this could lead to
If one block works better, it could become the standard for reducing pain after gallbladder surgery, helping patients recover faster with less medication.
What could go wrong
This is a small, early-stage trial with only 56 people. The results may not apply to everyone, and nerve blocks carry rare risks like infection or allergic reaction.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 56 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2025

An estimate. Start dates often move.

Expected to finish

Mar 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Age between 18 and 65 years Undergoing elective laparoscopic cholecystectomy Classified as American Society of Anesthesiologists (ASA) physical status I to III Providing written informed consent Exclusion Criteria: Known allergy or hypersensitivity to local anesthetics Infection or skin lesions at the site of block application Emergency surgical procedures Refusal to participate in the study Uncontrolled arterial hypertension Uncontrolled diabetes mellitus Mental retardation Current use of antidepressant medications Presence of metabolic disorders Known bleeding diathesis Morbid obesity (Body Mass Index \> 40 kg/m²)

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How to take part

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