Cure My Disease

Don't miss your cure!

 Log in / Sign up

Could a Ketamine-Like drug make emergency ICU intubations safer?

NCT ID NCT05464979

Disease control Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This trial tests whether esketamine, a drug related to ketamine, provides safer sedation than standard medications (midazolam and fentanyl) when critically ill patients need emergency breathing tubes in the ICU. Researchers will monitor blood pressure, heart rate, and oxygen levels before, during, and after the procedure. The goal is to see if esketamine leads to more stable vital signs and fewer complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
esketamine (a form of ketamine) given intravenously for sedation during emergency intubation
What this could lead to
If esketamine proves safer, it could become a preferred sedative for emergency intubations in the ICU, reducing complications.
What could go wrong
This is a small, early-phase trial with only 80 patients, so results may not apply broadly. Esketamine can cause side effects like increased heart rate or blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

80 people

The number who actually took part.

Started

Aug 2022

Finished

Jun 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged ≥ 18 years old without restriction of gender, race, religion, creed or nationality; * No use of sedatives within the half-life of their elimination before inclusion； * Patients and/or their family members know and agree to participate in the trial. Exclusion Criteria: * Age \<18 years,Allergy to esketamine or midazolam; * Endotracheal tract required intubation without notsedative drugs, such as cardiac arrest、neurologic dysfunction or the need for awake intubation * Patients with suspected elevated intracranial pressure; * Bradycardia (heartrate (HR) less than 50 beats / min) or atrioventricular block； * Untreated or undertreated hyperthyroid patients; * Chronic kidney disease; * Severe chronic liver disease (child-Pugh: Grade C); * Alcohol or opioid dependence, mental illness, or severe cognitive impairment; * Pregnancy or lactation; * Lack of informed consent.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Critically ill patients are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Critically ill patients

Contacts and locations

Locations

  • Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

    Wuhan, Hubei, 430022, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.