Could a Ketamine-Like drug make emergency ICU intubations safer?
NCT ID NCT05464979
First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time
Summary
This trial tests whether esketamine, a drug related to ketamine, provides safer sedation than standard medications (midazolam and fentanyl) when critically ill patients need emergency breathing tubes in the ICU. Researchers will monitor blood pressure, heart rate, and oxygen levels before, during, and after the procedure. The goal is to see if esketamine leads to more stable vital signs and fewer complications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- esketamine (a form of ketamine) given intravenously for sedation during emergency intubation
- What this could lead to
- If esketamine proves safer, it could become a preferred sedative for emergency intubations in the ICU, reducing complications.
- What could go wrong
- This is a small, early-phase trial with only 80 patients, so results may not apply broadly. Esketamine can cause side effects like increased heart rate or blood pressure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, 430022, China
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