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Breath analysis may offer a Needle-Free way to track critical Acid-Base balance

NCT ID NCT07782658

Knowledge-focused Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 24, 2026 · Last updated Aug 25, 2026 · Updated 1 time

Summary

This study tests whether a non-invasive device called indirect calorimetry—which measures carbon dioxide production and elimination through breathing—can accurately reflect changes in blood bicarbonate levels in critically ill patients. Currently, bicarbonate is measured through repeated blood draws, which are invasive and discontinuous. The researchers hypothesize that the mismatch between CO₂ production and elimination correlates with bicarbonate shifts. If confirmed, this could lead to continuous, non-invasive monitoring of acid-base status in the ICU, potentially improving patient care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Indirect calorimetry measurement (a non-invasive device that measures gas exchange to estimate metabolism)
What this could lead to
If confirmed, this could enable continuous, non-invasive monitoring of blood bicarbonate in ICU patients, reducing the need for repeated blood draws and allowing faster clinical adjustments.
What could go wrong
This is a small, early-stage study (91 patients) testing a hypothesis. The correlation may be weak or not hold in real-world conditions, and the device's accuracy could be affected by patient factors or ventilator settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 91 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2026

An estimate. Start dates often move.

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients admitted to the ICU

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patient admitted to the ICU within the past 72 hours * Receiving invasive mechanical ventilation * For whom the treating clinician plans to perform at least two blood bicarbonate measurements within the next 6 hours * No objection from the participant or their next of kin Exclusion Criteria: * Planned weaning from invasive mechanical ventilation or ventilator change before the second bicarbonate measurement * Conditions interfering with the interpretation of indirect calorimetry data: * Inspiratory oxygen fraction \> 60% * Administration of inhaled medications, including nitric oxide * Positive end-expiratory pressure (PEEP) \> 15 cmH₂O * Excessive leaks in the ventilator circuit, defined as expired volume \< 95% of inspired volume * Patient on mechanical circulatory support with a gas exchanger, or planned initiation before the second blood gas analysis * Patient on extracorporeal renal replacement therapy, or planned initiation before the second bicarbonate measurement * Patient who received sodium bicarbonate within 2 hours prior to inclusion, or planned administration before the second bicarbonate measurement * Frequent disconnections of the ventilator circuit, or planned bronchoscopy before the second bicarbonate measurement

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Conditions

The condition(s) this trial relates to.

disorder of acid-base balance

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acid-base disturbance Critically ill patients Indirect calorimetry

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Service d'Anesthésie-Réanimation, Hôpital Louis Pradel, Hospices Civils de Lyon

    Bron, Rhone, 69500, France

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