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Can a ventilator setting save energy for critically ill patients?

NCT ID NCT07790341

Knowledge-focused Sponsor: Diskapi Yildirim Beyazit Education and Research Hospital Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time

Summary

This study compares two ways of delivering mechanical ventilation in intensive care unit patients: pressure-controlled and volume-controlled synchronized intermittent mandatory ventilation. Researchers measure how much energy patients use with each mode using a technique called indirect calorimetry, which tracks oxygen consumption and carbon dioxide production. The goal is to see if one mode leads to lower energy expenditure while still providing adequate breathing support. The findings could help doctors tailor ventilator settings and nutrition for critically ill patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Two mechanical ventilation modes: pressure-controlled and volume-controlled synchronized intermittent mandatory ventilation
What this could lead to
If one mode proves less energy-demanding, it could guide ventilator settings to reduce patient effort and improve nutritional care in ICUs.
What could go wrong
This is a small observational study, so results may not apply broadly. Measuring energy use in critically ill patients is technically challenging and can be affected by many factors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 41 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Receiving invasive mechanical ventilation in the intensive care unit. Receiving continuous enteral nutrition during indirect calorimetry measurements.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Adults aged 18 to 80 years. * Receiving invasive mechanical ventilation in the intensive care unit. * Receiving continuous enteral nutrition during indirect calorimetry measurements. * Hemodynamically stable (mean arterial pressure ≥65 mmHg without significant increase in vasopressor requirement). * Technically suitable for indirect calorimetry measurements. * Written informed consent obtained from the patient or the legally authorized representative. Exclusion Criteria * Age \<18 years or \>80 years. * Pregnancy. * Hemodynamic instability. * High vasopressor requirement or marked increase in vasopressor dosage. * Requirement for frequent or major changes in ventilator settings or FiO₂. * FiO₂ \>0.60. * Bronchopleural fistula, significant air leak, or other pulmonary conditions interfering with indirect calorimetry. * Extracorporeal membrane oxygenation (ECMO). * Continuous renal replacement therapy (CRRT). * Significant body temperature fluctuations. * Active agitation or severe patient-ventilator dyssynchrony. * Acute metabolic changes that may interfere with indirect calorimetry measurements.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Indirect calorimetry Resting energy expenditure

How to take part

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  1. The official record

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