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Gum repair breakthrough? new combo treatment shows promise for Tooth-Saving surgery

NCT ID NCT07042204

Disease control Sponsor: Merna Nasser Mohamed Mostafa Ibrahim Elnahas Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study tested whether using a patient's own blood concentrate (ePRF) alone or mixed with bioactive glass nanoparticles can help repair bone defects in gum disease. Thirty adults with grade II furcation defects (bone loss between tooth roots) received one of three surgical treatments. The main goal was to measure bone fill using 3D X-rays.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
extended platelet-rich fibrin (ePRF) and bioactive glass nanoparticles
What this could lead to
If successful, this could point toward a better way to repair bone loss in gum disease, potentially improving tooth retention.
What could go wrong
This is a small, early-stage study with only 30 participants, so results may not apply widely. The treatments are surgical procedures, and outcomes depend on individual healing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Jan 2024

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Presence of Glickman's grade II furcation defects in molars probing depth (PD) ≥5 mm horizontal PD ≥3 mm. * The patients are in good systemic health and had not undergone any periodontal surgery in the areas to be treated within the prior 12 months. Exclusion Criteria: * Smokers and tobacco chewers. * Patients that take any medications within the past 6 months that could alter their periodontal status. * pregnant or lactating females. * Patients with known allergy to materials or drugs that will be used or prescribed in this study.

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Conditions

The condition(s) this trial relates to.

Furcation Defects

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Furcation defects

Contacts and locations

Locations

  • Mansoura University

    Al Mansurah, 35516, Egypt

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Other studies related to the condition(s) this trial covers.