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Can a Tooth-Enamel protein help rebuild bone lost to gum disease?

NCT ID NCT07776756

Disease control Sponsor: University of Medicine and Pharmacy at Ho Chi Minh City Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time

Summary

This trial tests whether combining a tooth-enamel protein with bone graft material can better repair furcation defects—areas where gum disease has destroyed bone between the roots of lower molars. Adults with periodontitis and such defects will receive one of two surgical treatments: the enamel protein plus bone graft, or a collagen membrane plus bone graft. Over about 7 months, the study compares pain, satisfaction, clinical measures, and imaging results to see if the enamel protein approach offers comparable or superior regeneration.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Enamel matrix derivative combined with xenograft bone, compared to xenograft bone with collagen membrane, used in periodontal regenerative surgery.
What this could lead to
If successful, this could offer a better surgical option for repairing tooth-supporting bone damage in people with gum disease, potentially saving teeth that might otherwise be lost.
What could go wrong
This is a small, early-stage trial with only 24 participants, so results may not apply broadly. Surgery carries risks like infection, pain, or incomplete healing, and the new combination may not outperform the standard approach.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 24 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older. * Full-mouth plaque score (FMPS) ≤ 20%. * Full-mouth bleeding score (FMBS) ≤ 20%. * Willingness to participate in the study and provide informed consent. * Mandibular first and/or second molar with a buccal Class II furcation defect classified as subgroup A2 or B2. * Probing pocket depth (PPD) ≥ 5 mm at the eligible furcation site. * Keratinized gingival height ≥ 2 mm at the eligible site. * No gingival recession extending apically beyond the buccal furcation roof; the furcation entrance must not be clinically exposed above the gingival margin. Exclusion Criteria: * Systemic diseases or conditions that may affect periodontal treatment outcomes, including uncontrolled diabetes mellitus, heart disease requiring anticoagulant therapy, hematologic disorders, or immunodeficiency. * Pregnancy or breastfeeding. * Untreated endodontic pathology involving the study tooth. * Class III furcation involvement according to the Hamp classification. * Untreated occlusal trauma involving the study tooth. * Grade II tooth mobility that has not been stabilized by splinting, or Grade III tooth mobility according to the Miller classification. * Defective restorations at the surgical site, including overhanging, bulky, or poorly adapted restorations.

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Class II furcation defect

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Faculty of Dentistry, University of Medicine and Pharmacy at Ho Chi Minh City

    RECRUITING

    Ho Chi Minh City, Binh Phu, 700000, Vietnam

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