E-Hookah nicotine may damage blood vessels, small study suggests

NCT ID NCT04133376

Completed Knowledge-focused Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether nicotine in electronic hookah (e-hookah) affects blood vessel function. Thirty-three healthy young adults who already used hookah or e-cigarettes vaped e-hookah with or without nicotine in separate sessions. Researchers measured blood vessel dilation and other markers of vascular health before and after vaping. The goal was to see if nicotine alone causes the blood vessel damage seen with e-hookah use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: electronic hookah vaping with or without nicotine
What this could lead to: If successful, this could clarify whether nicotine in e-hookah harms blood vessels, helping guide future regulations or safer product design.
What could go wrong: This is a small, early-stage study (33 people) that only measures short-term effects. Results may not apply to long-term use or to older or less healthy people.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Smoking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOTHELIAL DYSFUNCTION SMOKING

Contacts and locations

Locations

University of California, Los Angeles

Los Angeles, California, 90024, United States

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