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Bladder cancer drug combo shows promise in large global trial

NCT ID NCT03732677

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Nov 21, 2025 · Last updated May 15, 2026 · Updated 23 times

Summary

This study tests whether adding the immunotherapy drug durvalumab to standard chemotherapy before and after bladder removal surgery helps people with muscle-invasive bladder cancer. About 1,063 participants will receive either the drug combo or standard care. The goal is to see if the cancer disappears completely after treatment and if it delays the cancer from coming back.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Research Site

    Birmingham, Alabama, 35294, United States

  • Research Site

    Los Angeles, California, 90095, United States

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    Palo Alto, California, 94304, United States

  • Research Site

    New Haven, Connecticut, 06520, United States

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    Chicago, Illinois, 60611, United States

  • Research Site

    Geneva, Illinois, 60134, United States

  • Research Site

    Iowa City, Iowa, 52242, United States

  • Research Site

    Westwood, Kansas, 66205, United States

  • Research Site

    Louisville, Kentucky, 40202, United States

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    New Orleans, Louisiana, 70112, United States

  • Research Site

    Towson, Maryland, 21204, United States

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    Ann Arbor, Michigan, 48109, United States

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    Detroit, Michigan, 48201, United States

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    New York, New York, 10029, United States

  • Research Site

    Rochester, New York, 14642, United States

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    Bethlehem, Pennsylvania, 18015, United States

  • Research Site

    Burlington, Vermont, 05401, United States

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    Milwaukee, Wisconsin, 53226, United States

  • Research Site

    Brisbane, 4122, Australia

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    Elizabeth Vale, 5112, Australia

  • Research Site

    Macquarie University, 2109, Australia

  • Research Site

    Melbourne, 3004, Australia

  • Research Site

    Murdoch, 6150, Australia

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    South Brisbane, 4101, Australia

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    Bruges, 8000, Belgium

  • Research Site

    Charleroi, 6000, Belgium

  • Research Site

    Kortrijk, 8500, Belgium

  • Research Site

    Leuven, 3000, Belgium

  • Research Site

    Liège, 4000, Belgium

  • Research Site

    Roeselare, 8800, Belgium

  • Research Site

    Barretos, 14784-400, Brazil

  • Research Site

    Porto Alegre, 90020-090, Brazil

  • Research Site

    Porto Alegre, 90470-340, Brazil

  • Research Site

    Porto Alegre, 90610-000, Brazil

  • Research Site

    Porto Alegre, 91350-200, Brazil

  • Research Site

    Rio de Janeiro, 20231-050, Brazil

  • Research Site

    Santa Maria, 97015-450, Brazil

  • Research Site

    São José do Rio Preto, 15090-000, Brazil

  • Research Site

    São Paulo, 01246-000, Brazil

  • Research Site

    São Paulo, 01323-903, Brazil

  • Research Site

    São Paulo, 01509-900, Brazil

  • Research Site

    São Paulo, 03102-002, Brazil

  • Research Site

    Edmonton, Alberta, T6G 1Z2, Canada

  • Research Site

    Vancouver, British Columbia, V5Z 4E6, Canada

  • Research Site

    London, Ontario, N6A 5W9, Canada

  • Research Site

    Ottawa, Ontario, K1H 8L6, Canada

  • Research Site

    Toronto, Ontario, M5G IX6, Canada

  • Research Site

    Montreal, Quebec, H2X 0C2, Canada

  • Research Site

    Sherbrooke, Quebec, J1H 5N4, Canada

  • Research Site

    Antofagasta, 1267348, Chile

  • Research Site

    Port Montt, 5480000, Chile

  • Research Site

    Santiago, 7520349, Chile

  • Research Site

    Temuco, 4810218, Chile

  • Research Site

    Temuco, 4810469, Chile

  • Research Site

    Viña del Mar, 2540488, Chile

  • Research Site

    Brno, 656 53, Czechia

  • Research Site

    Brno, 656 91, Czechia

  • Research Site

    Hradec Králové, 500 05, Czechia

  • Research Site

    Olomouc, 77900, Czechia

  • Research Site

    Prague, 128 08, Czechia

  • Research Site

    Prague, 140 59, Czechia

  • Research Site

    Prague, 180 81, Czechia

  • Research Site

    Angers, 49033, France

  • Research Site

    Dijon, 21079, France

  • Research Site

    Grenoble, 38043, France

  • Research Site

    Montpellier, 34070, France

  • Research Site

    Nîmes, 30029, France

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    Pierre-Bénite, 69495, France

  • Research Site

    Poitiers, 86021, France

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    Rouen, F-76031 CE, France

  • Research Site

    Bergisch Gladbach, 51465, Germany

  • Research Site

    Bonn, 53127, Germany

  • Research Site

    Cologne, 50937, Germany

  • Research Site

    Erlangen, 91054, Germany

  • Research Site

    Göttingen, 37075, Germany

  • Research Site

    Herne, 44625, Germany

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    Jena, 07747, Germany

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    Magdeburg, 39120, Germany

  • Research Site

    Mannheim, 68167, Germany

  • Research Site

    Münster, 48149, Germany

  • Research Site

    Nuremberg, 90491, Germany

  • Research Site

    Oldenburg, 23758, Germany

  • Research Site

    Regensburg, 93053, Germany

  • Research Site

    Ulm, 89081, Germany

  • Research Site

    Würzburg, 97080, Germany

  • Research Site

    Haifa, 31096, Israel

  • Research Site

    Jerusalem, 91120, Israel

  • Research Site

    Kfar Saba, 95847, Israel

  • Research Site

    Petah Tikva, 4941492, Israel

  • Research Site

    Ramat Gan, 52621, Israel

  • Research Site

    Bari, 70124, Italy

  • Research Site

    Bologna, 40138, Italy

  • Research Site

    Florence, 50134, Italy

  • Research Site

    Milan, 20132, Italy

  • Research Site

    Milan, 20133, Italy

  • Research Site

    Naples, 80131, Italy

  • Research Site

    Orbassano, 10043, Italy

  • Research Site

    Pozzuoli, 80078, Italy

  • Research Site

    Verona, 37126, Italy

  • Research Site

    Bunkyō City, 113-8603, Japan

  • Research Site

    Fukuoka, 811-1347, Japan

  • Research Site

    Fukuoka, 812-8582, Japan

  • Research Site

    Hirosaki-shi, 036-8563, Japan

  • Research Site

    Hiroshima, 730-8518, Japan

  • Research Site

    Kanazawa, 920-8641, Japan

  • Research Site

    Kōtoku, 135-8550, Japan

  • Research Site

    Kumamoto, 860-0008, Japan

  • Research Site

    Miyazaki, 889-1692, Japan

  • Research Site

    Nagasaki, 852-8501, Japan

  • Research Site

    Nagoya, 466-8560, Japan

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    Niigata, 951-8520, Japan

  • Research Site

    Osaka, 541-8567, Japan

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    Osaka, 545-8586, Japan

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    Osakasayama-shi, 589-8511, Japan

  • Research Site

    Sendai, 980-0872, Japan

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    Toyama, 930-0194, Japan

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    Tsukuba, 305-8576, Japan

  • Research Site

    Yokohama, 232-0024, Japan

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    Yokohama, 241-8515, Japan

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    Amsterdam, 1066 CX, Netherlands

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    Amsterdam, 1081 HV, Netherlands

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    Breda, 4818 CK, Netherlands

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    Rotterdam, 3015 GD, Netherlands

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    Baguio City, 2600, Philippines

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    Cebu, 6000, Philippines

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    Davao City, 8000, Philippines

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    Makati, 1229, Philippines

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    Manila, 1015, Philippines

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    Quezon City, 1101, Philippines

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    Quezon City, 1104, Philippines

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    Bialystok, 15-027, Poland

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    Gdansk, 80-952, Poland

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    Grudziądz, 86-300, Poland

  • Research Site

    Koszalin, 75-581, Poland

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    Krakow, 30-510, Poland

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    Olsztyn, 10-228, Poland

  • Research Site

    Ostrołęka, 07-410, Poland

  • Research Site

    Poznan, 60-693, Poland

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    Warsaw, 02-781, Poland

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    Wroclaw, 53-413, Poland

  • Research Site

    Krasnoyarsk, 660133, Russia

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    Moscow, 105077, Russia

  • Research Site

    Nizhny Novgorod, 603074, Russia

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    Novosibirsk, 630007, Russia

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    Saint Petersburg, 194017, Russia

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    Saint Petersburg, 194044, Russia

  • Research Site

    Saint Petersburg, 194354, Russia

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    Saint Petersburg, 197022, Russia

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    Samara, 443031, Russia

  • Research Site

    Ufa, 450000, Russia

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    Vologda, 160012, Russia

  • Research Site

    Daegu, 41404, South Korea

  • Research Site

    Goyang-si, 10408, South Korea

  • Research Site

    Gyeonggi-do, 13620, South Korea

  • Research Site

    Incheon, 21565, South Korea

  • Research Site

    Seoul, 03080, South Korea

  • Research Site

    Seoul, 05505, South Korea

  • Research Site

    Seoul, 136-705, South Korea

  • Research Site

    Badalona, 08916, Spain

  • Research Site

    Barcelona, 08035, Spain

  • Research Site

    Córdoba, 14004, Spain

  • Research Site

    Las Palmas de Gran Canaria, 35016, Spain

  • Research Site

    Madrid, 28007, Spain

  • Research Site

    Madrid, 28041, Spain

  • Research Site

    Santander, 39008, Spain

  • Research Site

    Seville, 41013, Spain

  • Research Site

    Kaohsiung City, 807, Taiwan

  • Research Site

    Taichung, 404, Taiwan

  • Research Site

    Taichung, 40705, Taiwan

  • Research Site

    Tainan, 704, Taiwan

  • Research Site

    Tainan, 710, Taiwan

  • Research Site

    Taipei, 10050, Taiwan

  • Research Site

    Taipei, 11217, Taiwan

  • Research Site

    Taoyuan City, 333, Taiwan

  • Research Site

    Ankara, 06590, Turkey (Türkiye)

  • Research Site

    Cordaleo, 35575, Turkey (Türkiye)

  • Research Site

    Edirne, 22030, Turkey (Türkiye)

  • Research Site

    Istanbul, 34030, Turkey (Türkiye)

  • Research Site

    Istanbul, 34457, Turkey (Türkiye)

  • Research Site

    Izmir, Turkey (Türkiye)

  • Research Site

    Edinburgh, EH4 2XR, United Kingdom

  • Research Site

    London, E1 1BB, United Kingdom

  • Research Site

    Metropolitan Borough of Wirral, CH63 4JY, United Kingdom

  • Research Site

    Nottingham, NG5 1PB, United Kingdom

  • Research Site

    Sheffield, S10 2SJ, United Kingdom

  • Research Site

    Hanoi, 100000, Vietnam

  • Research Site

    Ho Chi Minh City, 700000, Vietnam

  • Research Site

    Hochiminh, 70000, Vietnam

Conditions

Explore the condition pages connected to this study.

MUSCLE-INVASIVE BLADDER CANCER