Can a steroid extend pain relief after shoulder surgery?
NCT ID NCT07795281
First seen Aug 31, 2026 · Last updated Sep 01, 2026 · Updated 1 time
Summary
This trial tests whether adding a steroid called dexamethasone to the standard pain regimen extends pain relief after arthroscopic shoulder surgery. Adults aged 18 to 65 receive a nerve block and dexmedetomidine, then either dexamethasone or a placebo before surgery. Researchers measure how long it takes before patients first ask for extra pain medication, along with pain scores, rebound pain, and side effects. The goal is to see if the combination safely improves recovery and reduces opioid use.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Intravenous dexamethasone added to intravenous dexmedetomidine
- What this could lead to
- If it works, this could give people having arthroscopic shoulder surgery longer-lasting pain relief after the nerve block wears off, reducing the need for strong painkillers.
- What could go wrong
- This is a small, early-phase trial, so the added benefit may be modest or not appear at all. Dexamethasone can raise blood sugar, and the study tracks this as a safety measure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 70 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Jan 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Patients aged 18 to 65 years. Patients classified as American Society of Anesthesiologists physical status I to III. Patients scheduled for elective arthroscopic shoulder surgery. Patients with a body mass index between 18.5 and 35 kg/m². Patients who are able to understand the study protocol and provide written informed consent. \- Exclusion Criteria: Patients younger than 18 years or older than 65 years. Patients classified as American Society of Anesthesiologists physical status IV or higher. Contraindications to peripheral nerve block, including coagulopathy or infection at the block site. Known allergy or contraindication to any of the drugs used in the study. Active gastrointestinal bleeding, history of peptic ulcer disease, or severe renal or hepatic insufficiency. History of chronic analgesic or opioid use. Pregnancy or breastfeeding. Presence of coagulopathy or use of anticoagulant or antiplatelet therapy. Requirement for additional sedation or general anesthesia during surgery. Neurological or psychiatric disease that may affect pain assessment. \-
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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