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Simple steroid shot before C-Section could cut Post-Op pain and opioid use

NCT ID NCT07718360

Symptom relief Sponsor: KRL Hospital, Islamabad Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This study investigates whether giving a single intravenous dose of the steroid dexamethasone before a planned cesarean section can reduce pain after the operation. Eighty women undergoing a scheduled C-section under spinal anesthesia are randomly assigned to receive either dexamethasone or a placebo (salt water). Pain levels are measured on a 0-10 scale at several time points after surgery, and the need for additional pain relief is tracked. The goal is to see if this simple, low-cost intervention can improve recovery and reduce reliance on other painkillers.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a single intravenous dose of dexamethasone (8 mg), a steroid medicine
What this could lead to
If effective, this simple, low-cost approach could become a standard way to improve pain control after cesarean sections, reducing the need for opioid painkillers.
What could go wrong
This is a small, single-center study with 80 participants. Results may not apply to all patients or settings, and the long-term effects of a single steroid dose in this context are not fully explored.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

80 people

The number who actually took part.

Started

Mar 2024

Finished

Sep 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Female patients aged 18-40 years 2. Scheduled for elective lower segment cesarean section (LSCS) 3. Spinal anesthesia planned and suitable 4. ASA physical status Class I or II 5. Gestational age ≥ 37 weeks 6. Willing to participate and able to provide written informed consent Exclusion Criteria: 1. Known allergy or hypersensitivity to dexamethasone or any corticosteroid 2. Diabetes mellitus or uncontrolled hyperglycemia 3. Current or recent (within 4 weeks) corticosteroid use 4. Contraindication to spinal anesthesia (coagulopathy, infection at puncture site, patient refusal) 5. Emergency cesarean section 6. Systemic infection or sepsis 7. Significant hepatic, renal, or cardiovascular disease 8. Peptic ulcer disease 9. Psychiatric illness 10. Failure of spinal anesthesia requiring conversion to general anesthesia 11. BMI \> 35 kg/m²

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cesarean section pain Postoperative pain Spinal anesthesia

Contacts and locations

Locations

  • KRL Hospital, Islamabad

    Islamabad, Federal Capital Territory, 44000, Pakistan

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