CRISPR One-Shot injection aims to permanently fix cholesterol genes
NCT ID NCT07491172
First seen Mar 24, 2026 · Last updated Apr 13, 2026 · Updated 1 time
Summary
This is a first-in-human safety study testing a new CRISPR-based gene therapy called CTX310. It aims to permanently edit a specific gene (ANGPTL3) to lower cholesterol and other blood fats in adults whose high cholesterol doesn't respond well to existing medications. Participants will receive a single intravenous infusion, and researchers will monitor their safety and how their cholesterol levels change over time.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Research Site 1
RECRUITINGAdelaide, 5000, Australia
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Research Site 10
NOT_YET_RECRUITINGJacksonville, Florida, 32216, United States
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Research Site 11
NOT_YET_RECRUITINGPort Orange, Florida, 32127, United States
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Research Site 12
NOT_YET_RECRUITINGPortland, Oregon, 97239, United States
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Research Site 13
NOT_YET_RECRUITINGHigh Point, North Carolina, 27260, United States
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Research Site 14
NOT_YET_RECRUITINGDurham, North Carolina, 27710, United States
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Research Site 15
NOT_YET_RECRUITINGBrisbane, 4064, Australia
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Research Site 16
NOT_YET_RECRUITINGBrisbane, Australia
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Research Site 17
NOT_YET_RECRUITINGOrlando, Florida, 32789, United States
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Research Site 18
NOT_YET_RECRUITINGCambridge, United Kingdom
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Research Site 2
RECRUITINGMelbourne, 3168, Australia
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Research Site 3
RECRUITINGHeidelberg, 3084, Australia
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Research Site 4
RECRUITINGChristchurch, 8011, New Zealand
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Research Site 5
RECRUITINGAuckland, 2025, New Zealand
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Research Site 6
RECRUITINGLondon, SE1 1YR, United Kingdom
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Research Site 7
NOT_YET_RECRUITINGCamperdown, 2050, Australia
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Research Site 8
NOT_YET_RECRUITINGLondon, E1 1BB, United Kingdom
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Research Site 9
NOT_YET_RECRUITINGCleveland, Ohio, 44195, United States
Conditions
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