Simple CPAP right after birth may keep late preterm babies out of the NICU

NCT ID NCT05204719

Completed Disease control Sponsor: University of Oklahoma Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tested whether giving late preterm babies (34-37 weeks) born by C-section a short course of CPAP breathing support right after delivery could reduce their need for extra oxygen or breathing help. 120 babies were randomly assigned to receive either early CPAP or standard care. The goal was to see if this simple step could lower NICU admissions and improve breathing outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Continuous Positive Airway Pressure (CPAP)
What this could lead to: If it works, this simple breathing support right after birth could reduce the need for intensive care and help more late preterm babies breathe on their own.
What could go wrong: This is a small pilot study, so results may not apply to all babies. The treatment is short-term and not a cure for prematurity.

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Conditions

The condition(s) this trial relates to.

Premature Birth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PREMATURE BIRTH

Contacts and locations

Locations

Indiana University

Indianapolis, Indiana, 46202, United States
Pontificia Universidad Católica de Chile

Santiago, Santiago Metropolitan, 8331150, Chile
Saint Louis University

St Louis, Missouri, 63104, United States
The University of Oklahoma Health Campus

Oklahoma City, Oklahoma, 73104, United States
University of Alberta

Edmonton, Alberta, T5H 3V9, Canada

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