Which CLL drug combo gives best value for older patients?

NCT ID NCT02414022

First seen May 12, 2026 ยท Last updated May 12, 2026

Summary

This study looked at the costs and quality-of-life benefits of three different drug combinations for older adults (65 and up) with chronic lymphocytic leukemia (CLL). Researchers compared a standard chemo-immunotherapy (bendamustine plus rituximab) with two newer ibrutinib-based regimens. The goal was to see which treatment offers the best value for the Canadian healthcare system by measuring quality-adjusted life-years (QALYs) and overall costs.

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Contacts and locations

Locations

  • Allan Blair Cancer Centre

    Regina, Saskatchewan, Canada

  • CHUM-CEntre Hospitalier de l'Universite de Montreal

    Montreal, Quebec, Canada

  • CSSS Champlain-Charles LeMoyne

    Greenfield Park, Quebec, Canada

  • Health Sciences North

    Greater Sudbury, Ontario, Canada

  • Humber River Hospital

    Toronto, Ontario, Canada

  • Juravinski Cancer Centre at Hamilton Health Sciences

    Hamilton, Ontario, Canada

  • Kingston Health Sciences Centre

    Kingston, Ontario, K7L3N6, Canada

  • London Regional Cancer Program

    London, Ontario, Canada

  • Odette Cancer Centre Sunnybrook Health Sciences Centre

    Toronto, Ontario, Canada

  • Ottawa Hospital Research Institute

    Ottawa, Ontario, Canada

  • Stronach Regional Health Centre at Southlake

    Newmarket, Ontario, L3Y 2P9, Canada

  • The Jewish General Hospital

    Montreal, Quebec, Canada

  • The Moncton Hospital

    Moncton, New Brunswick, Canada

  • Tom Baker Cancer Centre

    Calgary, Alberta, Canada

  • University Health Network Princess Margaret Cancer Centre

    Toronto, Ontario, Canada

Conditions

Explore the condition pages connected to this study.