Could a simple saliva test replace blood draws for cortisol screening?
NCT ID NCT07350031
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at whether a saliva test can accurately measure cortisol levels after a dexamethasone suppression test, compared to the standard blood test. Researchers studied about 100 patients with adrenal incidentalomas (non-cancerous growths on the adrenal gland) and 100 healthy volunteers. If saliva testing proves reliable, it could offer a simpler, less invasive way to screen for excess cortisol production.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
1 mg overnight dexamethasone suppression test (diagnostic test)
What this could lead to
If successful, this could make screening for cortisol excess easier and less invasive by using saliva instead of blood tests.
What could go wrong
This is a completed observational study, not a treatment trial. Saliva testing may not be as accurate as blood testing in all patients, and results may not change current clinical practice.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.