Could a simple saliva test replace blood draws for cortisol screening?

NCT ID NCT07350031

Completed Diagnosis Sponsor: Rigshospitalet, Denmark Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether a saliva test can accurately measure cortisol levels after a dexamethasone suppression test, compared to the standard blood test. Researchers studied about 100 patients with adrenal incidentalomas (non-cancerous growths on the adrenal gland) and 100 healthy volunteers. If saliva testing proves reliable, it could offer a simpler, less invasive way to screen for excess cortisol production.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 1 mg overnight dexamethasone suppression test (diagnostic test)
What this could lead to: If successful, this could make screening for cortisol excess easier and less invasive by using saliva instead of blood tests.
What could go wrong: This is a completed observational study, not a treatment trial. Saliva testing may not be as accurate as blood testing in all patients, and results may not change current clinical practice.

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Conditions

The condition(s) this trial relates to.

adrenal cortex adenoma Adrenal incidentaloma Cushing syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADRENAL INCIDENTALOMA HYPERCORTISOLISM

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