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Can a combined program help veterans in substance use care quit smoking?

NCT ID NCT07809854

Symptom relief Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 09, 2026 · Last updated Sep 15, 2026 · Updated 3 times

Summary

Veterans in outpatient substance use treatment smoke at high rates and often do not get help to quit. Researchers at the VA are testing a program called Co-STOP that pairs nicotine replacement therapy with counseling and delivers it alongside substance use care. The trial enrolls 112 veterans who smoke at least one cigarette daily and are already in VA substance use treatment. Researchers measure whether participants use nicotine replacement and attend counseling, and whether they make at least one 24-hour quit attempt.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nicotine replacement therapy (gum or mini-lozenge) plus a program that combines smoking treatment with substance use care
What this could lead to
If it works, the VA could have a practical way to get more veterans in substance use treatment to use nicotine replacement and attempt quitting.
What could go wrong
This is a small, early study, so the program may not improve quit rates or may not fit other VA settings. Nicotine replacement can cause mouth irritation, nausea, or headaches.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 112 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2027

An estimate. Start dates often move.

Expected to finish

Sep 2031

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Smoke at least one cigarette per day * Be engaged in VA outpatient substance use treatment for at least one month * Be medically eligible to use Nicotine Replacement Therapy (NRT) * Not currently receiving smoking treatment * Not currently at high risk for suicide * Have an email address Exclusion Criteria: * Unable to give informed, voluntary consent to participate * Incarceration

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Conditions

The condition(s) this trial relates to.

Cigarette Smoking substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cigarette smoking Veterans

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • William S. Middleton Memorial Veterans Hospital, Madison, WI

    Madison, Wisconsin, 53705-2254, United States

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